Ligand for E3 Ligase
The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.
The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.
Products Related to Ligand for E3 Ligase(166)
- GC35929E3 ligase Ligand 15CAS: 2306390-08-7Purity: >98%
E3 ligase Ligand 15 (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 15 can be connected to the ligand for protein by a linker to form PROTACs.
- GC35930E3 ligase Ligand 16CAS: 2249750-27-2Purity: >98.00%
E3 ligase Ligand 16 (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTAC.
- GC35932E3 ligase Ligand 18CAS: 2241669-88-3Purity: >98%
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
- GC35933E3 ligase Ligand 8CAS: 1225383-33-4Purity: >98.50%
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
- GC38579Lenalidomide-BrCAS: 2093387-36-9Purity: >98.50%
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36.
- GC38724(S,R,S)-AHPC-propargylCAS: 2098799-78-9Purity: >98%
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs.
- GC38862Thalidomide-propargylCAS: 2098487-39-7Purity: >98%
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs.
- GC39609(S,S,S)-AHPC hydrochlorideCAS: 2115897-23-7Purity: >99.50%
(S,S,S)-AHPC hydrochloride is a VHL E3 ligase ligand based on VH032.
- GC46008(±)-Thalidomide-d4CAS: 1219177-18-0Purity: >99.00%
An internal standard for the quantification of (±)-thalidomide
- GC50623VH 101, phenolCAS: 2306193-99-5Purity: >99.00%
VH 101, phenol is the VH032-based VHL ligand. VH 101, phenol can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.
- GC60223Lenalidomide-OHCAS: 1416990-08-3Purity: >99.00%
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620.
- GC60360Thalidomide 5-fluorideCAS: 835616-61-0Purity: >99.00%
Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
- GC60361Thalidomide-5-OHCAS: 64567-60-8Purity: >98.00%
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
- GC60362Thalidomide-O-C8-BocCAS: 2225148-52-5Purity: >95.00%
Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs.
- GC60363Thalidomide-O-C8-COOHCAS: 2225148-51-4Purity: >98%
Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.
- GC62147Lenalidomide-ICAS: 2207541-30-6Purity: >98.50%
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570.
- GC62218CRBN modulator-1CAS: 2407829-65-4Purity: >98.00%
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
- GC62283(S,R,S)-AHPCCAS: 1448297-52-6Purity: >98.00%
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
- GC62378Thalidomide-NH-CH2-COOHCAS: 927670-97-1Purity: >98.00%
Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
- GC62541Lenalidomide-5-BrCAS: 1010100-26-1Purity: >99.00%
Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC35929 | E3 ligase Ligand 15 | 2306390-08-7 | >98% | |
E3 ligase Ligand 15 (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 15 can be connected to the ligand for protein by a linker to form PROTACs. | ||||
| GC35930 | E3 ligase Ligand 16 | 2249750-27-2 | >98.00% | |
E3 ligase Ligand 16 (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTAC. | ||||
| GC35932 | E3 ligase Ligand 18 | 2241669-88-3 | >98% | |
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. | ||||
| GC35933 | E3 ligase Ligand 8 | 1225383-33-4 | >98.50% | |
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. | ||||
| GC38055 | BC-1215 | 1507370-20-8 | >98% | |
An inhibitor of FBXO3 | ||||
| GC38579 | Lenalidomide-Br | 2093387-36-9 | >98.50% | |
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36. | ||||
| GC38724 | (S,R,S)-AHPC-propargyl | 2098799-78-9 | >98% | |
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs. | ||||
| GC38862 | Thalidomide-propargyl | 2098487-39-7 | >98% | |
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. | ||||
| GC39609 | (S,S,S)-AHPC hydrochloride | 2115897-23-7 | >99.50% | |
(S,S,S)-AHPC hydrochloride is a VHL E3 ligase ligand based on VH032. | ||||
| GC46008 | (±)-Thalidomide-d4 | 1219177-18-0 | >99.00% | |
An internal standard for the quantification of (±)-thalidomide | ||||
| GC50364 | cis VH 298 | 2097381-86-5 | >98% | |
Negative control for VH 298 | ||||
| GC50623 | VH 101, phenol | 2306193-99-5 | >99.00% | |
VH 101, phenol is the VH032-based VHL ligand. VH 101, phenol can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4. | ||||
| GC60223 | Lenalidomide-OH | 1416990-08-3 | >99.00% | |
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620. | ||||
| GC60360 | Thalidomide 5-fluoride | 835616-61-0 | >99.00% | |
Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. | ||||
| GC60361 | Thalidomide-5-OH | 64567-60-8 | >98.00% | |
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs. | ||||
| GC60362 | Thalidomide-O-C8-Boc | 2225148-52-5 | >95.00% | |
Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs. | ||||
| GC60363 | Thalidomide-O-C8-COOH | 2225148-51-4 | >98% | |
Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs. | ||||
| GC60963 | KB02-COOH | 2375196-30-6 | >98.50% | |
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF. | ||||
| GC61452 | VH032 | 1448188-62-2 | >99.50% | |
VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a Kd</b of 185 nM. VH032 can be connected to the ligand for protein by a linker to form PROTACs. | ||||
| GC62147 | Lenalidomide-I | 2207541-30-6 | >98.50% | |
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570. | ||||
| GC62218 | CRBN modulator-1 | 2407829-65-4 | >98.00% | |
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM. | ||||
| GC62283 | (S,R,S)-AHPC | 1448297-52-6 | >98.00% | |
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. | ||||
| GC62378 | Thalidomide-NH-CH2-COOH | 927670-97-1 | >98.00% | |
Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032. | ||||
| GC62541 | Lenalidomide-5-Br | 1010100-26-1 | >99.00% | |
Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC. | ||||