Ligand for E3 Ligase
The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.
The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.
Products Related to Ligand for E3 Ligase(166)
- GC73249Thalidomide-5-O-C7-NH2 hydrochloridePurity: >98.00%
Thalidomide-5-O-C7-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73250Thalidomide-5-O-C8-NH2 hydrochloride
Thalidomide-5-O-C8-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73251Thalidomide-5-O-C9-NH2 hydrochloridePurity: >99.00%
Thalidomide-5-O-C9-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73252Thalidomide-5-O-C10-NH2 hydrochloridePurity: >99.00%
Thalidomide-5-O-C10-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73253Thalidomide-5-O-C11-NH2 hydrochloride
Thalidomide-5-O-C11-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73254Thalidomide-5-O-C12-NH2 hydrochloridePurity: >99.00%
Thalidomide-5-O-C12-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73255Thalidomide-5-O-C13-NH2 hydrochloridePurity: >99.00%
Thalidomide-5-O-C13-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73256Thalidomide-5-O-C14-NH2 hydrochloridePurity: >97.00%
Thalidomide-5-O-C14-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73257Thalidomide-4-O-C11-NH2 hydrochloridePurity: >99.00%
Thalidomide-4-O-C11-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73258Thalidomide-4-O-C12-NH2 hydrochloridePurity: >95.00%
Thalidomide-4-O-C12-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73259Thalidomide-4-O-C14-NH2 hydrochloridePurity: >99.00%
Thalidomide-4-O-C14-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73330VHL Ligand 14CAS: 2010986-87-3Purity: >99.00%
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM.
- GC73469Cereblon inhibitor 2CAS: 2639380-62-2Purity: >98.00%
Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer.
- GC73556Thalidomide-5-PEG6-NH2 hydrochloride
Thalidomide-5-PEG6-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73557Thalidomide-5-PEG7-NH2 hydrochloride
Thalidomide-5-PEG7-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73617Thalidomide-NH-C9-NH2 hydrochlorideCAS: 2305936-77-8
Thalidomide-NH-C9-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.
- GC73618Thalidomide-NH-C14-NH2 hydrochloride
Thalidomide-NH-C14-NH2 drochloride is a Thalidomide -based cereblon ligand that recruits CRBN proteins.
- GC74725BWA-522 intermediate-1CAS: 2241315-66-0Purity: >99.00%
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 and serves as a ligand molecule for cereblon E3 ubiquitin ligase.
- GC80888PROTAC PLK1 Degrader-2Purity: >99.00%
PROTAC PLK1 Degrader-2 is a peptide-based N-end rule PLK1 mini-PROTAC.
- GC80948CRBN ligand-882CAS: 1512414-62-8Purity: >98.00%
CRBN ligand-882 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73249 | Thalidomide-5-O-C7-NH2 hydrochloride | - | >98.00% | |
Thalidomide-5-O-C7-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73250 | Thalidomide-5-O-C8-NH2 hydrochloride | - | - | |
Thalidomide-5-O-C8-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73251 | Thalidomide-5-O-C9-NH2 hydrochloride | - | >99.00% | |
Thalidomide-5-O-C9-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73252 | Thalidomide-5-O-C10-NH2 hydrochloride | - | >99.00% | |
Thalidomide-5-O-C10-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73253 | Thalidomide-5-O-C11-NH2 hydrochloride | - | - | |
Thalidomide-5-O-C11-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73254 | Thalidomide-5-O-C12-NH2 hydrochloride | - | >99.00% | |
Thalidomide-5-O-C12-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73255 | Thalidomide-5-O-C13-NH2 hydrochloride | - | >99.00% | |
Thalidomide-5-O-C13-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73256 | Thalidomide-5-O-C14-NH2 hydrochloride | - | >97.00% | |
Thalidomide-5-O-C14-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73257 | Thalidomide-4-O-C11-NH2 hydrochloride | - | >99.00% | |
Thalidomide-4-O-C11-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73258 | Thalidomide-4-O-C12-NH2 hydrochloride | - | >95.00% | |
Thalidomide-4-O-C12-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73259 | Thalidomide-4-O-C14-NH2 hydrochloride | - | >99.00% | |
Thalidomide-4-O-C14-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73330 | VHL Ligand 14 | 2010986-87-3 | >99.00% | |
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM. | ||||
| GC73469 | Cereblon inhibitor 2 | 2639380-62-2 | >98.00% | |
Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer. | ||||
| GC73474 | CC-3060 | 444288-86-2 | >99.00% | |
CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. | ||||
| GC73556 | Thalidomide-5-PEG6-NH2 hydrochloride | - | - | |
Thalidomide-5-PEG6-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73557 | Thalidomide-5-PEG7-NH2 hydrochloride | - | - | |
Thalidomide-5-PEG7-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73611 | VHL-IN-1 | 3033117-53-9 | >99.00% | |
VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. | ||||
| GC73617 | Thalidomide-NH-C9-NH2 hydrochloride | 2305936-77-8 | - | |
Thalidomide-NH-C9-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein. | ||||
| GC73618 | Thalidomide-NH-C14-NH2 hydrochloride | - | - | |
Thalidomide-NH-C14-NH2 drochloride is a Thalidomide -based cereblon ligand that recruits CRBN proteins. | ||||
| GC73891 | PT-179 | 2924858-25-1 | >98.00% | |
PT-179 is an orthogonal Thalidomide derivative that targets cereblon without causing off-target degradation effects. | ||||
| GC74725 | BWA-522 intermediate-1 | 2241315-66-0 | >99.00% | |
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 and serves as a ligand molecule for cereblon E3 ubiquitin ligase. | ||||
| GC80854 | (R)-BMS-986470 | - | >99.50% | |
(R)-BMS-986470 is the enantiomer of BMS-986470. | ||||
| GC80888 | PROTAC PLK1 Degrader-2 | - | >99.00% | |
PROTAC PLK1 Degrader-2 is a peptide-based N-end rule PLK1 mini-PROTAC. | ||||
| GC80948 | CRBN ligand-882 | 1512414-62-8 | >98.00% | |
CRBN ligand-882 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. | ||||