Ligand for E3 Ligase

Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.

Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.

ALV2 is an effective and selective degrader of Helios (IKZF2). ALV2 binds to CRBN with an IC 50 of 0.57μM.

Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC

Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk).

CFT7455 is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. CFT7455 is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM) (WO2022032132A1; Compound 1).

CC-99282 is a potent and orally active cereblon (CRBN) E3 ligase modulator (CELMoD). CC-99282 co-opts CRBN to induce potent and targeted degradation of Ikaros and Aiolos. CC-99282 can be used for researching non-Hodgkin lymphomas.

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma.

VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC.

CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC.

AR antagonist 1 (compound 29) hydrochloride is an effective AR antagonist that binds to E3 ligand and has weak affinity for VHL protein. It is used in the synthesis of PROTAC ARD-266.

BODIPY FL thalidomide is a high-affinity fluorescent probe for human brain proteins, with a Kd value of 3.6 nM.

DCAF1 binder 1 selectively binds to the CRL4 DCAF1 E3 ligase complex. It is a ligand for E3 Ligase used for targeted protein degradation (TPD).

E3 ligase Ligand 23 (compound 17-6) is a cereblon binder used to degrade Ikaros or Aiolos through the ubiquitin-proteasome pathway.

SJPYT-195 is a cell-toxic degradation product of GSPT1 that can be used for synthesizing PROTAC.

Beta-naphthoflavone-CH2-Br is an aryl hydrocarbon receptor (AhR) ligand. It is used in the synthesis of PROTAC Beta-NF-JQ1.

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development.

PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development.

Thalidomide-4-O-C7-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.

Thalidomide-5-O-C2-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.

Thalidomide-5-O-C3-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.

Thalidomide-5-O-C4-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.

Thalidomide-5-O-C5-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.

Thalidomide-5-O-C6-NH2 drochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.