Leukotriene B4 Ethanolamide (Synonyms: LTB4EA) |
| Catalog No.GC44053 |
The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 877459-63-7
Sample solution is provided at 25 µL, 10mM.
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The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM. LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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