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PKC

PKC (protein kinase C) is a serine/threonine protein kinase that mediates insulin signaling, actin cytoskeleton, cell mobility, apoptosis and tumorigenesis etc.

Products for  PKC

  1. Cat.No. Product Name Information
  2. GC17014 Ro 31-8220 Mesylate Pan-PKC inhibitor Ro 31-8220 Mesylate  Chemical Structure
  3. GC10029 Ro 31-8220 methanesulfonate Ro 31-8220 methanesulfonate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 methanesulfonate  Chemical Structure
  4. GC13677 Ro 32-0432 hydrochloride protein kinase C inhibitor Ro 32-0432 hydrochloride  Chemical Structure
  5. GC10820 Rottlerin PKC inhibitor Rottlerin  Chemical Structure
  6. GC63177 Ruboxistaurin Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin  Chemical Structure
  7. GC16405 Safingol PKC and sphingosine kinases inhibitor Safingol  Chemical Structure
  8. GC63439 Sangivamycin Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers. Sangivamycin  Chemical Structure
  9. GC11022 SB 218078 checkpoint kinase 1 (Chk1) inhibitor SB 218078  Chemical Structure
  10. GC13320 SC-10 Protein kinase C activator SC-10  Chemical Structure
  11. GC18055 SC-9 protein kinase C activator SC-9  Chemical Structure
  12. GC15520 Sotrastaurin (AEB071) Sotrastaurin (AEB071) (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively. Sotrastaurin (AEB071)  Chemical Structure
  13. GC15299 Staurosporine(CGP 41251)

    A potent inhibitor of protein kinase C

    Staurosporine(CGP 41251)  Chemical Structure
  14. GC10682 TAS 301

    inhibitor of smooth muscle cell migration and proliferation, inhibits PKC signaling

    TAS 301  Chemical Structure
  15. GC16678 UCN-02 protein kinase C inhibitor UCN-02  Chemical Structure
  16. GC16934 Valrubicin chemotherapy drug used to treat bladder cancer Valrubicin  Chemical Structure
  17. GC13232 Verbascoside PKC/NF-κB inhibitor Verbascoside  Chemical Structure
  18. GC31912 VTX-27 VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ. VTX-27  Chemical Structure
  19. GC26055 WAY-301398 WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC). WAY-301398  Chemical Structure
  20. GC26065 WAY-354831 WAY-354831 exhibits antibacterial activity. WAY-354831  Chemical Structure
  21. GC70166 Z-Arg-SBzl

    Z-Arg-SBzl is a substrate for activating protein C in both cows and humans.

    Z-Arg-SBzl  Chemical Structure
  22. GC13273 ZIP ZIP is a selective peptide inhibitor of PKMζ. ZIP  Chemical Structure
  23. GC13461 ZIP (SCRAMBLED) PKMζ inhibitor ZIP (SCRAMBLED)  Chemical Structure
  24. GC16510 ZIP, Biotinylated ZIP with a biotin moiety covalently attached ZIP, Biotinylated  Chemical Structure
  25. GC14701 Zoledronic Acid Potent nitrogen-containing bisphosphonates Zoledronic Acid  Chemical Structure
  26. GC17727 [Ala107]-MBP (104-118) Non-competitive inhibitor of PKC [Ala107]-MBP (104-118)  Chemical Structure
  27. GC15345 [Ala113]-MBP (104-118) Non-competitive inhibitor of PKC [Ala113]-MBP (104-118)  Chemical Structure
  28. GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9 nM. α-Amyloid Precursor Protein Modulator  Chemical Structure
  29. GC62478 ζ-Stat ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro. ζ-Stat  Chemical Structure

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