PKC
PKC (protein kinase C) is a serine/threonine protein kinase that mediates insulin signaling, actin cytoskeleton, cell mobility, apoptosis and tumorigenesis etc.
Products for PKC
- Cat.No. Product Name Information
- GC17014 Ro 31-8220 Mesylate Pan-PKC inhibitor
- GC10029 Ro 31-8220 methanesulfonate Ro 31-8220 methanesulfonate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
- GC13677 Ro 32-0432 hydrochloride protein kinase C inhibitor
- GC10820 Rottlerin PKC inhibitor
- GC63177 Ruboxistaurin Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (Ki=2 nM).
- GC16405 Safingol PKC and sphingosine kinases inhibitor
- GC63439 Sangivamycin Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.
- GC11022 SB 218078 checkpoint kinase 1 (Chk1) inhibitor
- GC13320 SC-10 Protein kinase C activator
- GC18055 SC-9 protein kinase C activator
- GC15520 Sotrastaurin (AEB071) Sotrastaurin (AEB071) (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.
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GC15299
Staurosporine(CGP 41251)
A potent inhibitor of protein kinase C
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GC10682
TAS 301
inhibitor of smooth muscle cell migration and proliferation, inhibits PKC signaling
- GC16678 UCN-02 protein kinase C inhibitor
- GC16934 Valrubicin chemotherapy drug used to treat bladder cancer
- GC13232 Verbascoside PKC/NF-κB inhibitor
- GC31912 VTX-27 VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ.
- GC26055 WAY-301398 WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).
- GC26065 WAY-354831 WAY-354831 exhibits antibacterial activity.
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GC70166
Z-Arg-SBzl
Z-Arg-SBzl is a substrate for activating protein C in both cows and humans.
- GC13273 ZIP ZIP is a selective peptide inhibitor of PKMζ.
- GC13461 ZIP (SCRAMBLED) PKMζ inhibitor
- GC16510 ZIP, Biotinylated ZIP with a biotin moiety covalently attached
- GC14701 Zoledronic Acid Potent nitrogen-containing bisphosphonates
- GC17727 [Ala107]-MBP (104-118) Non-competitive inhibitor of PKC
- GC15345 [Ala113]-MBP (104-118) Non-competitive inhibitor of PKC
- GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9 nM.
- GC62478 ζ-Stat ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro.