GLPBio

ROR/RAR/RXR

RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

Products Related to ROR/RAR/RXR(92)

  • GC12598 structure
    GC12598AGN 194310
    CAS: 229961-45-9
    Purity: >98.00%

    pan-RAR antagonist

  • GC17094 structure
    GC17094Acitretin
    CAS: 55079-83-9
    Purity: >99.00%

    Acitretin is a second-generation aromatic retinoid drug. Acitretin binds to Retinoic Acid Receptor (RAR) α/β/γ and retinoid X receptor (RXR) to regulate gene transcription.

  • GC10037 structure
    GC10037Bexarotene
    CAS: 153559-49-0
    Purity: >99.50%

    Bexarotene is a selective activator of retinoid X receptor (RXR), with EC 50 values of 0.028, 0.025, and 0.020µM for RXRα, RXRβ and RXRγ, respectively.

  • GC10064 structure
    GC10064Flurizan
    CAS: 51543-40-9
    Purity: >99.50%

    A COX-inactive enantiomer of flurbiprofen

  • GC10080 structure
    GC10080CD 2314
    CAS: 170355-37-0
    Purity: >98%

    RARβ agonist,potent and selective

  • GC10212 structure
    GC10212MM 11253
    CAS: 345952-44-5
    Purity: >98.00%

    RARγ antagonist

  • GC10610 structure
    GC10610Adapalene
    CAS: 106685-40-9
    Purity: >98.00%

    Adapalene, a chemically stable derivative of naphthoic acid, is a potent retinoic acid receptor (RAR) agonist, with K D values of 1.1μM, 34nM, and 130nM for RARα, RARβ, and RARγ, respectively.

  • GC10656 structure
    GC10656BMS 453
    CAS: 166977-43-1
    Purity: >98.50%

    RAR agonist

  • GC10871 structure
    GC10871AC 55649
    CAS: 59662-49-6
    Purity: >99.50%

    RARβ2 agonist, potent and selective

  • GC11053 structure
    GC11053Ch 55
    CAS: 110368-33-7
    Purity: >99.50%

    RAR agonist

  • GC11464 structure
    GC11464CD 437
    CAS: 125316-60-1
    Purity: >98.00%

    RARγ-selective agonist,potent and cell-permeable

  • GC11504 structure
    GC11504BMS 195614
    CAS: 182135-66-6
    Purity: >98%

    BMS 195614 (BMS 614) is a neutral RARα-selective antagonist with a Ki of 2.5 nM.

  • GC11676 structure
    GC11676EC 23
    CAS: 104561-41-3
    Purity: >99.00%

    retinoic acid receptors agonist

  • GC11694 structure
    GC11694Fluorobexarotene
    CAS: 1190848-23-7
    Purity: >98%

    RXR agonist

  • GC11794 structure
    GC11794CD 1530
    CAS: 107430-66-0
    Purity: >98.00%

    RAR receptor agonist

  • GC11852 structure
    GC11852AC 261066
    CAS: 870773-76-5
    Purity: >98%

    Potent RARβ2 agonist

  • GC12072 structure
    GC12072CD 2665
    CAS: 170355-78-9
    Purity: >98.00%

    Selective RARβ/γ antagonist

  • GC12294 structure
    GC12294LE 135
    CAS: 155877-83-1
    Purity: >99.00%

    RARβ antagonist

  • GC12577 structure
    GC12577ER 50891
    CAS: 187400-85-7
    Purity: >98%

    RARα receptor antagonist

  • GC13199 structure
    GC13199UVI 3003
    CAS: 847239-17-2
    Purity: >98.00%

    RXR antagonist

  • GC13959 structure
    GC13959Adarotene
    CAS: 496868-77-0
    Purity: >99.00%

    An atypical retinoid

  • GC13984 structure
    GC13984Tamibarotene
    CAS: 94497-51-5
    Purity: >99.50%

    A selective RARα agonist

  • GC14185 structure
    GC14185BMS 753
    CAS: 215307-86-1
    Purity: >98%

    RARα-selective agonist

  • GC14273 structure
    GC14273TTNPB (Arotinoid Acid)
    CAS: 71441-28-6
    Purity: >99.00%

    TTNPB (Arotinoid Acid) is a selective retinoic acid receptor (RAR) agonist. TTNPB competitively binds to RARα (IC 50 =5.1nM), RARβ (IC 50 =4.5nM), and RARγ (IC 50 =9.3nM).