MM 11253 |
| Catalog No.GC10212 |
RARγ antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 345952-44-5
Sample solution is provided at 25 µL, 10mM.
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MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).1 It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; to inhibit the growth of oral squamous cell carcinoma cells in vitro.[1]
Reference:
[1]. Le, Q.T., Dawson, M.I., Soprano, D.R., et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene 19(11), 1457-1465 (2000).
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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