GLPBio

SMAD

SMAD are intracellular proteins that transduce extracellular signals from transforming growth factor beta ligands to the nucleus where they activate downstream gene transcription.

Products Related to SMAD(18)

  • GC16580 structure
    GC16580LDN-193189
    CAS: 1062368-24-4
    Purity: >99.00%

    ALK inhibitor,potent and selective

  • GC14931 structure
    GC14931LDN193189 Hydrochloride
    CAS: 1062368-62-0
    Purity: >98.50%

    LDN193189 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

  • GC15057 structure
    GC15057Kartogenin
    CAS: 4727-31-5
    Purity: >98.00%

    Kartogenin is an inducer of cartilage-like tissue formation (EC 50 : 100nM)

  • GC16793 structure
    GC16793RepSox
    CAS: 446859-33-2
    Purity: >98.00%

    RepSox is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) with an IC 50 of 23nM. RepSox inhibits ALK5 autophosphorylation with an IC 50 of 4nM.

  • GC17191 structure
    GC17191SIS3 HCl
    CAS: 521984-48-5
    Purity: >98.00%

    SIS3 HCl is a Smad3 inhibitor that inhibits the phosphorylation of Smad3 with an IC 50 of 3 μM.

  • GC17523 structure
    GC17523Hydrochlorothiazide
    CAS: 58-93-5
    Purity: >99.00%

    diuretic drug of the thiazide class

  • GC19338 structure
    GC19338SRI-011381 hydrochloride
    CAS: 2070014-88-7
    Purity: >98.00%

    SRI-011381 hydrochloride is an orally active activator of the transforming growth factor β (TGF-β) signaling pathway with neuroprotective effects.

  • GC31650 structure
    GC31650Halofuginone (RU-19110)
    CAS: 55837-20-2
    Purity: >98.00%

    Halofuginone (RU-19110) (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM.

  • GC31950 structure
    GC31950Halofuginone hydrobromide (RU-19110 (hydrobromide))
    CAS: 64924-67-0
    Purity: >99.50%

    Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM.

  • GC32250 structure
    GC32250Chebulinic acid
    CAS: 18942-26-2
    Purity: >98.00%

    An ellagitannin with diverse biological activities

  • GC32914 structure
    GC32914EMT inhibitor-1
    CAS: 1638526-21-2
    Purity: >99.00%

    EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

  • GC34060 structure
    GC34060Disitertide (P144)
    CAS: 272105-42-7
    Purity: >98.00%

    Disitertide (P144) (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) (P144) is also a PI3K inhibitor and an apoptosis inducer.

  • GC41863 structure
    GC4186310,11-dehydro Curvularin
    CAS: 21178-57-4
    Purity: >98.00%

    A natural mycotoxin

  • GC44903 structure
    GC44903SMAD3 Inhibitor, SIS3
    CAS: 1009104-85-1
    Purity: >98.00%

    SMAD3 Inhibitor, SIS3 is a potent and selective inhibitor of Smad3 phosphorylation.

  • GN10378 structure
    GN10378Oxymatrine
    CAS: 16837-52-8
    Purity: >98.00%

    Oxymatrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens.

  • GN10534 structure
    GN10534Asiaticoside
    CAS: 16830-15-2
    Purity: >98.00%

    Asiaticoside is a pentacyclic triterpenoid glycoside extracted from Centella asiatica .

  • GC11604 structure
    GC11604LY364947
    CAS: 396129-53-6
    Purity: >99.00%

    LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC 50 of 59nM.

  • GC12790 structure
    GC12790Pirfenidone
    CAS: 53179-13-8
    Purity: >98.00%

    Pirfenidone (AMR69) is an orally active antifibrotic drug that attenuates the production of chemokines CCL2 and CCL12 in fibrocytes .