KLA peptide acetate is a naturally occurring Antibiotic peptide that is nontoxic outside of cells but is toxic when it enters into the interior of targeted cells. KLA peptide acetate can induce cell Apoptosis by disrupting mitochondrial membrane s and activating Caspase. MG1-KLA acetate, formed by the coupling of KLA peptide acetate with MG1, can selectively induce apoptosis in pro-inflammatory microglia. KLA peptide acetate can be used for the research of liver fibrosis. KLA peptide acetate can be used for the research of neonatal hypoxic-ischemic encephalopathy [1] [2].
In Vitro, When acting alone, the KLA peptide (in FITC-KLA form; 50-200 μM; 30 min) acetate exhibits negligible cell-penetrating activity in HSC-T6 cells[1].
References:
[1]. Guo Z, et al. Specific hepatic stellate cell-penetrating peptide targeted delivery of a KLA peptide reduces collagen accumulation by inducing apoptosis. J Drug Target. 2017 Sep;25(8):715-723.
[2]. Zen R, et al. Pro-inflammatory microglia-targeted peptide therapy ameliorates neonatal hypoxic-ischemic encephalopathy in mice. Mol Ther. 2025 Jul 2;33(7):3177-3194.
In Vitro, When acting alone, the KLA peptide (in FITC-KLA form; 50-200 μM; 30 min) acetate exhibits negligible cell-penetrating activity in HSC-T6 cells[1].
References:
[1]. Guo Z, et al. Specific hepatic stellate cell-penetrating peptide targeted delivery of a KLA peptide reduces collagen accumulation by inducing apoptosis. J Drug Target. 2017 Sep;25(8):715-723.
[2]. Zen R, et al. Pro-inflammatory microglia-targeted peptide therapy ameliorates neonatal hypoxic-ischemic encephalopathy in mice. Mol Ther. 2025 Jul 2;33(7):3177-3194.