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Inicio >> Signaling Pathways >> Proteases >> Mitochondrial Metabolism

Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Targets for  Mitochondrial Metabolism

Products for  Mitochondrial Metabolism

  1. Cat.No. Nombre del producto Información
  2. GC19941 DL-Leucic Acid DL-Leucic Acid Chemical Structure
  3. GC40539 (±)12(13)-EpOME

    (±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid

     (±)12(13)-EpOME is the 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. (±)12(13)-EpOME Chemical Structure
  4. GC40801 (±)9(10)-DiHOME

    Leukotoxin diol

     (±)9(10)-DiHOME es el racemato de 9,10-DiHOME. (±)9(10)-DiHOME Chemical Structure
  5. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

    Un fenol con diversas actividades biológicas.

     (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  6. GC41721 (R)-α-Lipoic Acid

    (R)-(+)-Lipoic Acid

     (R)-α-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant. (R)-α-Lipoic Acid Chemical Structure
  7. GC18596 (±)-2-propyl-4-Pentenoic Acid

    2-Allylpentanoic Acid, 4-ene VPA

    El Ácido (±)-2-propil-4-pentenoico (4-en-VPA) es un metabolito tÓxico principal del Ácido valproico. (±)-2-propyl-4-Pentenoic Acid Chemical Structure
  8. GC19528 1,4-Benzoquinone

    p-Benzoquinone, NSC 36324, p-Quinone

     A toxic metabolite of benzene 1,4-Benzoquinone Chemical Structure
  9. GC46451 16F16 A PDI inhibitor 16F16 Chemical Structure
  10. GC90815 2',3'-cyclic NADP+ (sodium salt)

    Un sustrato para CNP

     2',3'-cyclic NADP+ (sodium salt) Chemical Structure
  11. GC90803 2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)

    Un inhibidor de la transcriptasa inversa y un metabolito activo de ddA y ddI.

     2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt) Chemical Structure
  12. GC42193 2-Thenoyltrifluoroacetone

    NSC 66544, NSC 405702, NSC 405703, NSC 405704, NSC 405705, NSC 405706, TTFA

     La 2-tenoiltrifluoroacetona es un agente quelante. 2-Thenoyltrifluoroacetone Chemical Structure
  13. GC49849 3-Aminosalicylic Acid

    3-ASA, NSC 285111

     A salicylic acid derivative 3-Aminosalicylic Acid Chemical Structure
  14. GC45615 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt)

    DL-3-hydroxy-3-methylglutaryl-CoA, HMG-CoA, Hydroxymethylglutaryl-CoA

     A neuropeptide with diverse biological activities 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt) Chemical Structure
  15. GC46599 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)

    DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3

     A neuropeptide with diverse biological activities 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt) Chemical Structure
  16. GC42351 4-carboxy TEMPO

    4-Carboxyl-2,2,6,6-tetramethylpiperidin-1-oxyl

     4-carboxy TEMPO is a nitroxide and spin label. 4-carboxy TEMPO Chemical Structure
  17. GC49722 4-CF3-TPP-DC

    4-CF3-Triphenylphosphonium-DC

     An inert mitochondriotropic carrier 4-CF3-TPP-DC Chemical Structure
  18. GC41310 5-Octyl-α-ketoglutarate

    αKG octyl ester

     In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate Chemical Structure
  19. GC46779 Acequinocyl A naphthoquinone acaricide Acequinocyl Chemical Structure
  20. GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)

    Acetoacetyl-CoA

    Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.

     Acetoacetyl Coenzyme A (sodium salt hydrate) Chemical Structure
  21. GC46789 Acetyl-L-carnitine-d3 (chloride)

    ALCAR-d3, L-Acetylcarnitine-d3, C2:0 Carnitine-d3, CAR 2:0-d3, L-Carnitine acetyl ester-d3

     An internal standard for the quantification of L-acetylcarnitine Acetyl-L-carnitine-d3 (chloride) Chemical Structure
  22. GC19021 Adjudin

    AF-2364

     Adjudin es un anticonceptivo masculino ampliamente estudiado con un efecto inhibidor de mitocondrias superior. Adjudin también es un potente bloqueador de los canales de Cl. Adjudin Chemical Structure
  23. GC42742 ADT-OH

    ACS1

     ADT-OH es un donante liberador de sulfuro de hidrÓgeno. ADT-OH induce la apoptosis e inhibe el desarrollo de melanoma in vivo mediante la regulaciÓn positiva de FADD. ADT-OH tiene potencial para la investigaciÓn de enfermedades cancerosas. ADT-OH Chemical Structure
  24. GC46812 Aflatoxin G1-13C17 An internal standard for the quantification of aflatoxin G1 Aflatoxin G1-13C17 Chemical Structure
  25. GC46814 Aflatoxin M1-13C17

    AFM1-13C17

     A neuropeptide with diverse biological activities Aflatoxin M1-13C17 Chemical Structure
  26. GC35262 Afzelin

    Kaempferin, Kaempferol 3-O-rhamnoside, Kaempferol 3-O-α-L-rhamnopyranoside

     Afzelin (Kaempferol-3-O-rhamnoside) es un glucÓsido de flavonol que se encuentra en Houttuynia cordata Thunberg y se usa ampliamente en la preparaciÓn de agentes antibacterianos y antipiréticos, desintoxicantes y para el tratamiento de la inflamaciÓn. Afzelin Chemical Structure
  27. GC63642 Agaric acid El Ácido agÁrico (Ácido agaricÍnico) se obtiene de varias plantas de la tribu fÚngica, i. Agaric acid Chemical Structure
  28. GC18437 Alternariol monomethyl ether

    AME, NSC 638262

     El éter monometÍlico de alternariol, aislado de las raÍces de Anthocleista djalonensis (Loganiaceae), es un importante marcador taxonÓmico de la especie vegetal. Alternariol monomethyl ether Chemical Structure
  29. GC18274 Amiprofos-methyl

    APM, NSC 313446

     El amiprofos-metilo (BAY-NTN 6867) es un herbicida de amida fosfórica. Amiprofos-methyl Chemical Structure
  30. GC42818 Antimycin A1 La antimicina A1 es un inhibidor especÍfico de la transferencia de electrones de la ubiquinol-citocromo c oxidorreductasa. La antimicina A1 inhibe la angiogénesis a través de la disminuciÓn de la producciÓn de VEGF provocada por la inhibiciÓn de la activaciÓn de HIF-1α. Antimycin A1 Chemical Structure
  31. GC18621 Antimycin A2 Antimycin A2 is an active component of the antimycin A antibiotic complex. Antimycin A2 Chemical Structure
  32. GC42819 Antimycin A3 Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4. Antimycin A3 Chemical Structure
  33. GC42820 Antimycin A4 Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1, antimycin A2, and antimycin A3. Antimycin A4 Chemical Structure
  34. GC42821 AP219 AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. AP219 Chemical Structure
  35. GC42823 AP39 AP39 es un anetol ditioletiona derivatizado con trifenilfosfonio y un donante de sulfuro de hidrÓgeno (H2S) dirigido a las mitocondrias. AP39 Chemical Structure
  36. GC42846 Arachidonoyl-L-carnitine (chloride)

    C20:4 Carnitine​

    Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism.

     Arachidonoyl-L-carnitine (chloride) Chemical Structure
  37. GC46883 AS-2077715 An inhibitor of fungal complex III AS-2077715 Chemical Structure
  38. GC31432 Asp-AMS

    Asp-AMS, un análogo de aspartil-adenilato, es un inhibidor de la aspartil-ARNt sintetasa y también un fuerte inhibidor competitivo de la enzima mitocondrial.

     Asp-AMS Chemical Structure
  39. GC42874 Aureothin

    Antibiotic 74A, BRN 0058476, JA 2814K, Mycolutein, Strain 58 substance

     Aureothin is a natural nitroaryl-substituted polyketide that exhibits antitumor, antifungal, and insecticidal activities. Aureothin Chemical Structure
  40. GC40677 Avenaciolide

    (±)-Avenaciolide

     La avenaciolida es una bis-γ-lactona antifÚngica que se encuentra en Aspergillus avenaceus. Avenaciolide Chemical Structure
  41. GC18580 B355252 B355252, una molécula pequeña de fenoxi tiofeno sulfonamida, es un potente agonista del receptor de NGF. B355252 Chemical Structure
  42. GC49901 BAY-179 BAY-179 es un inhibidor del complejo I potente, selectivo y de reacciÓn cruzada entre especies (IC50 = 79 μM). BAY-179 Chemical Structure
  43. GC49403 Benzarone

    L 2197, NSC 82134

     La benzarona (Fragivix) es un potente inhibidor del transportador de Ácido Úrico humano 1 (hURAT1), con una IC50 de 2,8 μM en el ovocito. Benzarone Chemical Structure
  44. GC49318 Benzovindiflupyr A fungicide Benzovindiflupyr Chemical Structure
  45. GC41252 BI-6C9 BI-6C9 es un inhibidor del dominio de interacciÓn BH3 altamente especÍfico (Bid), que previene el potencial de membrana externa mitocondrial (MOMP) y la fisiÓn mitocondrial, y protege a las células de la liberaciÓn del factor inductor de apoptosis mitocondrial (AIF) y la muerte celular independiente de caspasa en las neuronas. 1]. BI-6C9 Chemical Structure
  46. GC72916 Biguanide Biguanide es un agente antiperglicémico activo por vía oral. Biguanide Chemical Structure
  47. GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt)

    DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)

     A Bim-derived peptide BimS BH3 (51-76) (human) (trifluoroacetate salt) Chemical Structure
  48. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278 Chemical Structure
  49. GC46943 Boscalid A broad-spectrum carboxamide fungicide Boscalid Chemical Structure
  50. GC42978 Bromamphenicol Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol. Bromamphenicol Chemical Structure
  51. GC43030 C16 dihydro Ceramide (d18:0/16:0)

    Cer(d18:0/16:0) ; Ceramide (d18:0/16:0); N-hexadecanoyl-D-erythro-Dihydrosphingosine; N-Palmitoyl Sphinganine

    A bioactive sphingolipid

     C16 dihydro Ceramide (d18:0/16:0) Chemical Structure
  52. GC91157 C18

    Un inhibidor covalente de GPX4.

     C18 Chemical Structure
  53. GC48425 C18 D-threo Ceramide (d18:1/18:0)

    D-threo Cer(d18:1/18:0), D-threo Ceramide (d18:1/18:0), N-octadecanoyl-D-threo-Sphingosine, N-stearoyl-D-threo-Sphingosine

     A synthetic ceramide C18 D-threo Ceramide (d18:1/18:0) Chemical Structure
  54. GC49806 C18 Ganglioside GD3-d3 (ammonium salt)

    Disialosyllactosylceramide-d3, N-omega-CD3-Octadecanoyl Disialoganglioside GD3-d3

     An internal standard for the quantification of ganglioside GD3 C18 Ganglioside GD3-d3 (ammonium salt) Chemical Structure
  55. GC43050 C18 L-erythro Ceramide (d18:1/18:0)

    L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine

     C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. C18 L-erythro Ceramide (d18:1/18:0) Chemical Structure
  56. GC43051 C18 L-threo Ceramide (d18:1/18:0)

    N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)

     C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. C18 L-threo Ceramide (d18:1/18:0) Chemical Structure
  57. GC43052 C18 Phytoceramide (t18:0/18:0)

    Cer(t18:0/18:0), Ceramide (t18:0/18:0), N-Octadecanoyl Phytosphingosine, C18:0 Phytoceramide, SPS, N-Stearoyl Phytosphingosine

     C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. C18 Phytoceramide (t18:0/18:0) Chemical Structure
  58. GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3)

    Cer(t18:0/18:0) - d3, Ceramide (t18:0/18:0)- d3, N-Octadecanoyl Phytosphingosine- d3, C18:0 Phytoceramide- d3, N-Stearoyl Phytosphingosine- d3

     C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) by GC- or LC-MS. C18 Phytoceramide-d3 (t18:0/18:0-d3) Chemical Structure
  59. GC43069 C22 Ceramide (d18:1/22:0)

    C22 Ceramide；Cer(d18:1/22:0)；Ceramide (d18:1/22:0)

     C22 Ceramide (d18:1/22:0) is a long-chain ceramide containing behenic acid isolated from the sea sponge Haliclona koremella and is an endogenous bioactive sphingolipid. C22 Ceramide (d18:1/22:0) Chemical Structure
  60. GC43141 Carboxyatractyloside (potassium salt) Carboxyatractyloside is a natural heteroglucoside produced in some plants, including A. Carboxyatractyloside (potassium salt) Chemical Structure
  61. GC43195 CAY10703 Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. CAY10703 Chemical Structure
  62. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  63. GC14727 CCCP

    Carbonyl cyanide m-chlorophenyl hydrazone, NSC 88124

     El Carbonilcianuro-m-clorofenilhidrazona (CCCP) es un protóforo, que causa el desacoplamiento del gradiente de protones en la membrana interna mitocondrial, inhibiendo así la tasa de síntesis de ATP. CCCP Chemical Structure
  64. GC65208 CCI-006 CCI-006 es un inhibidor selectivo y quimiosensibilizador de las células de leucemia reorganizadas por MLL, al inhibir la respiraciÓn mitocondrial, lo que da como resultado una despolarizaciÓn mitocondrial insuperable y una respuesta de proteÍna desplegada (UPR) proapoptÓtica en un subconjunto de células de leucemia MLL-r. CCI-006 Chemical Structure
  65. GC45410 cis-6-Hexadecenoic Acid-d19

    C16:1(6Z)-d19, C16:1Δ6-d19, C16:1ω10c-d19, Sapienic Acid-d19

       cis-6-Hexadecenoic Acid-d19 Chemical Structure
  66. GC47096 Citrinin-13C13

    (-)-Citrinin-13C13, CTN-13C13

     A neuropeptide with diverse biological activities Citrinin-13C13 Chemical Structure
  67. GC43289 Cochlioquinone B Cochlioquinone is a sesquiterpene metabolite originally isolated from C. Cochlioquinone B Chemical Structure
  68. GC47114 Coenzyme A (lithium salt hydrate)

    CoA

     An essential cofactor in enzymatic acetyl transfer reactions Coenzyme A (lithium salt hydrate) Chemical Structure
  69. GC43295 Coenzyme A (sodium salt hydrate)

    CoA

     Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A (sodium salt hydrate) Chemical Structure
  70. GC47116 Coenzyme Q10-d6

    CoQ10-d6, Ubidecarenone-d6, Ubiquinone-10-d6, Ubiquinone Q10-d6

    Un estándar interno para la cuantificación de CoQ10.

     Coenzyme Q10-d6 Chemical Structure
  71. GC43297 Coenzyme Q2

    CoQ2, Ubiquinone-2, Ubiquinone Q2

     Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2 Chemical Structure
  72. GC49454 Complex 3 A fluorescent copper complex with anticancer activity Complex 3 Chemical Structure
  73. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases Coumarin-Quinone Conjugate Chemical Structure
  74. GC91800 CPPA-TPP

    CPPA-Triphenylphosphonium,4-Cyano-4-(phenylcarbonothioylthio)pentanoic Acid-TPP,4-Cyano-4-(phenylcarbonothioylthio)pentanoic-Triphenylphosphonium

     CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP Chemical Structure
  75. GC19138 CTPI-2 CTPI-2 es un inhibidor de SLC25A1 portador de citrato mitocondrial de tercera generaciÓn con una KD de 3,5 μM. CTPI-2 Chemical Structure
  76. GC43345 Cyclohexanoyl Coenzyme A

    CHCoA, Cyclohexanecarboxyl-CoA

     Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. Cyclohexanoyl Coenzyme A Chemical Structure
  77. GC49863 Cytarabine 5′-monophosphate

    ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445

     An active metabolite of cytarabine Cytarabine 5′-monophosphate Chemical Structure
  78. GC45800 Cytarabine-13C3

    Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3

     A neuropeptide with diverse biological activities Cytarabine-13C3 Chemical Structure
  79. GC25337 D-Carnitine hydrochloride

    (S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride

     D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. D-Carnitine hydrochloride Chemical Structure
  80. GN10072 Daidzin

    Daidzoside, NPI 031D

     Daidzin Chemical Structure
  81. GC47176 Decanoyl-Coenzyme A (hydrate)

    Decanoyl-CoA

     A neuropeptide with diverse biological activities Decanoyl-Coenzyme A (hydrate) Chemical Structure
  82. GC47177 Decanoyl-L-carnitine (hydrate)

    CAR 10:0, C10:0 Carnitine, L-Carnitine decanoyl ester, (-)-Decanoylcarnitine, L-Decanoylcarnitine

     A neuropeptide with diverse biological activities Decanoyl-L-carnitine (hydrate) Chemical Structure
  83. GC47178 Decanoyl-L-carnitine-d3 (chloride)

    CAR 10:0-d3, C10:0 Carnitine-d3, (-)-Decanoylcarnitine-d3, L-Carnitine decanoyl ester-d3, L-Decanoylcarnitine-d3

     A neuropeptide with diverse biological activities Decanoyl-L-carnitine-d3 (chloride) Chemical Structure
  84. GC40538 Decylubiquinone La decilubiquinona es un anÁlogo de la ubiquinona (coenzima Q10). Decylubiquinone Chemical Structure
  85. GC18869 Deoxyenterocin

    5-Deoxyenterocin

     Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. Deoxyenterocin Chemical Structure
  86. GC49022 Didanosine-d2

    ddl-d2, 2′,3′-Dideoxyinosine-d2

     An internal standard for the quantification of didanosine Didanosine-d2 Chemical Structure
  87. GC38620 Dihydrorotenone

    La dihidrorotenona, un pesticida natural, es un potente inhibidor mitocondrial.

     Dihydrorotenone Chemical Structure
  88. GC43463 DiIC1(5) DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. DiIC1(5) Chemical Structure
  89. GC47238 Diquat (bromide) El diquat (bromuro) es un herbicida integral comÚnmente utilizado en el cultivo de algodÓn, soja y otros cultivos para combatir las malas hierbas no deseadas. Diquat (bromide) Chemical Structure
  90. GC47239 Diquat-d12 (bromide) A neuropeptide with diverse biological activities Diquat-d12 (bromide) Chemical Structure
  91. GC47240 Diquat-d4 (bromide) A neuropeptide with diverse biological activities Diquat-d4 (bromide) Chemical Structure
  92. GC43498 DL-α-Lipoic Acid

    Thioctic Acid

     DL-α-El Ácido lipoico es un antioxidante, que es un cofactor esencial de los complejos enzimÁticos mitocondriales. DL-α-Lipoic Acid Chemical Structure
  93. GC47243 DL-Carnitine-d9 (chloride)

    (±)-Carnitine-d9

     An internal standard for the quantification of carnitine DL-Carnitine-d9 (chloride) Chemical Structure
  94. GC43543 DNP-INT DNP-INT is a quinone analog that inhibits electron transport in plants by competitively inhibiting plastoquinol oxidation by binding at the Qo site of cytochrome b6f (Kd = 1.4 nM). DNP-INT Chemical Structure
  95. GC18439 Doxorubicinone

    Adriamycin aglycone, Adriamycinone, aglycone-DOX, Doxorubicin aglycone, Epirubicin aglycone

     La doxorrubicinana es un metabolito de un agente de quimioterapia contra el cÁncer, la doxorrubicina. La doxorrubicina es un potente inhibidor de la topoisomerasa I y la topoisomerasa II del ADN humano con IC50 de 0,8 μM y 2,67 μM, respectivamente. Doxorubicinone Chemical Structure
  96. GC47274 DS44960156 DS44960156 es un inhibidor selectivo de la metilentetrahidrofolato deshidrogenasa 2 (MTHFD2), con valores de IC50 de 1,6 μM y >30 μM para MTHFD2 y MTHFD1, respectivamente. DS44960156 Chemical Structure
  97. GC18992 Duclauxin

    NSC 258308

     Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells. Duclauxin Chemical Structure
  98. GC34569 Elamipretide TFA Elamipretide TFA Chemical Structure
  99. GC72090 Elamipretide triacetate Elamipretide triacetate (MTP-131 triacetato; Triacetato RX-31; SS-31 triacetato) es Elamipretide triacetate forma de elamipretida. Elamipretide triacetate Chemical Structure
  100. GC32858 ER-000444793 ER-000444793 es un potente inhibidor de la apertura del poro de transiciÓn de permeabilidad mitocondrial (mPTP). ER-000444793 inhibe mPTP con un IC50 de 2.8μM. ER-000444793 Chemical Structure
  101. GC14328 FCCP

    Trifluoromethoxy carbonylcyanide phenylhydrazone

     FCCP, un transportador de protones (H+ ionóforo), es también un potente agente de acoplamiento que difunde ácido fosfórico, promoviendo la despolarización de la membrana plasmática y de la membrana mitocondrial. FCCP Chemical Structure

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