Angiogenesis

cRGDfK-thioacetyl ester TFA es una molécula biopolipeptídica. El péptido cRGDfK tiene una afinidad selectiva por las integrinas. El péptido cRGDfK puede modificar las sondas fluorescnir para la obtención de imágenes de cáncer.

Veltuzumab (IMMU-106) es un anticuerpo monoclonal humanianti-cd20.

2-Methylbutyrylcarnitine chloride es un metabolimicrobiintestinal que se une a la integrina − 2 − 1 en las plaquetas, potencila activación de la fosfolipasa A2 citosólica (cPLA2) y la perrespuesta plaquetaria.

MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins.

Furtisetabart is a humanized monoclonal antibody targeting CD147 with anti-tumor activity.

Fibronectin active fragment control acetate is an active peptide fragment of fibronectin.

α4β7 Integrin-IN-2 is an inhibitor of human α4β7 integrin with an IC 50 <5 nM.

GREDVGC is a peptide.

c-RGD-SH TFA is an Integrin αvβ3 ligand.

Deethyl-emvistegrast TFA is a quinoline derivative and also a α4β7 integrin inhibitor.

C16Y acetate is a short peptide and an inhibitor of integrins αvβ3 and α5β1.

Cyclo(-RGDfK), 5/6 FAM labeled TFA is a Cyclo(-RGDfK) TFA labeled with 5/6 FAM.

T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a K d of 10 nM for human transferrin receptor.

mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX).

PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] .

ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM.

HIF-IN-2 is a HIF/HIF prolyl hydroxylase inhibitor.

Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.

(S,R)-Emvistegrast ((S,R)-GS-1427) is an isomer of Emvistegrast.

IOX2 -NH2 (example 115) is a derivative of IOX2.

(R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg.

NP1192 is a potent, selective PROTAC NAT10 degrader.

PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.

NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader.