GLPBio

PARP

PARP Inhibitors

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Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

Products Related to PARP(147)

  • GC70420 structure
    GC70420Amelparib
    CAS: 1227156-72-0
    Purity: >99.00%

    Amelparib es un potente inhibidor de PARP-1, activo por vía oral y soluble en agua.

  • GC70421 structure
    GC70421Amelparib hydrochloride
    Purity: >98.00%

    Amelparib hydrochloride es un potente inhibidor de PARP-1, activo por vía oral y soluble en agua.

  • GC71552 structure
    GC71552TNKS-2-IN-1
    CAS: 4765-59-7
    Purity: >95.00%

    TNKS-2-IN-1 (compuesto 13g) es un inhibidor TNKS-2.

  • GC72849 structure
    GC72849rel-PROTAC PARP1 degrader
    Purity: >98.00%

    rel-PROTAC PARP1 degrader es la configuración relativa del degrader ROTAC PARP1.

  • GC73130 structure
    GC73130Basroparib
    CAS: 1858179-75-5
    Purity: >98.00%

    Basroparib es un potente inhibide la polipolimerasa poli (adp-ribosa) (PARP), con actividad antineoplásica.

  • GC73136 structure
    GC73136VPC-70063
    CAS: 13571-44-3
    Purity: >99.00%

    VPC-70063 es un potente inhibidor de Myc-Max con un valor de IC50 de 8.9 μM para inhibide la actividad transcripcional de Myc-Max.

  • GC73184 structure
    GC73184OUL232
    CAS: 943119-42-4
    Purity: >99.00%

    OUL232 es un potente inhibidor de PARP7, PARP10, PARP11, PARP12, PARP14 y PARP15.

  • GC73272 structure
    GC73272PARP-1-IN-3
    CAS: 2976342-33-1
    Purity: >99.00%

    PARP-1-IN-3, un derivado de la benzamida, es un potente inhibidor de PARP-1 con valores de IC50 de 0,25 nM y 2,34 nM para PARP-1 y PARP-2, respectivamente.

  • GC73566 structure
    GC73566PARP7-IN-15
    CAS: 2819998-97-3
    Purity: >98.00%

    PARP7-IN-15 (compuesto 18) es un inhibidor de PARP7 con IC50 de 0,56 nM, que tiene actividad antitumoral.

  • GC73633 structure
    GC73633TNKS-2-IN-2
    CAS: 2719726-91-5
    Purity: >99.00%

    TNKS-2-IN-2 es un potente y selectivo inhibidor del TNKS2 con una IC50 de 22 nM.

  • GC73639 structure
    GC73639PARP7-IN-16
    CAS: 2435657-10-4
    Purity: >95.00%

    PARP7-IN-16 (compuesto 36) es un potente inhibidor de PARP-1/2/7, con IC50s de 0,94, 0,87 y 0,21 nM, respectivamente.

  • GC73640 structure
    GC73640PARP7-IN-16 free base
    CAS: 2136325-05-6

    PARP7-IN-16 free base es la forma de base libre de PARP7-IN-16.

  • GC73642 structure
    GC73642ALK-IN-26
    CAS: 2447607-85-2
    Purity: >99.00%

    ALK-IN-26 es un inhibidor de ALK con un valor de IC50 de 7.0 μM para la tirosina quinasa ALK.

  • GC73760 structure
    GC73760Trilexium
    CAS: 1983180-82-0
    Purity: >99.00%

    Trilexium (TRX-E-009-1) es una tercera generación de benzopirano estructuralmente relacionado con TRX-E-002-1.

  • GC73919 structure
    GC73919AZD-9574-acid
    CAS: 2923687-90-3

    AZD-9574-acid (70D), un inhibide PPAR-1, puede ser utilizado para la síntesis de PROTAC (CAS 2923686-70-6).

  • GC73943 structure
    GC73943Polθ/PARP-IN-1
    Purity: >99.00%

    Polθ/PARP-IN-1 (compuesto 25d) es un potente inhibidor dual de la polimerasa de ADN Theta (Polθ) y PARP con valores de IC50 de 45,6, 5,4 nM, respectivamente.

  • GC74078 structure
    GC74078PARP1-IN-29
    CAS: 1567375-93-2

    PARP1-IN-29 es un inhibidor de PARP-1 activo por vía oral con un valor de IC50 de 6,3 nM.

  • GC78810 structure
    GC78810Anisomelic acid
    CAS: 59632-76-7
    Purity: >98%

    Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor.

  • GC78957 structure
    GC78957(2S,3R,4S)-ASX-173
    CAS: 2748800-07-7
    Purity: >99.00%

    (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.

  • GC78958 structure
    GC78958TMLB-C16
    CAS: 2923531-50-2
    Purity: >99.00%

    TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM.

  • GC78961 structure
    GC78961GPS167
    CAS: 3034312-19-8
    Purity: >98%

    GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4.

  • GC79050 structure
    GC79050OUL312
    Purity: >99.00%

    OUL312 is a potent PARP10 inhibitor ( IC 50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 ( IC 50 = 1500 nM).

  • GC79056 structure
    GC79056KMR-206
    CAS: 2992741-10-1
    Purity: >99.50%

    KMR-206 is a PARP7 inhibitor with an IC 50 of 13.7 nM.

  • GC79058 structure
    GC79058PARP1/NAMPT-IN-1
    CAS: 3084810-86-3
    Purity: >98.00%

    PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC 50 values of 1.2 nM and 6.7 nM, respectively.