GLPBio

Wu-5

Catalog No.: GC73501Purity:>98.00%
COASDSData Sheet
Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

Products are for research use only. Not for human use. We do not sell to patients.

Wu-5
Cas No.: 2630378-05-9
1 mgIn Stock
$86.00
1
5 mgIn Stock
$216.00
1
10 mgIn Stock
$342.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

Description

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

Wu-5 (10 μM; 24, 48, 72 h) selectively induces the death of FLT3-ITD-positive AML cells[1].Wu-5 (1, 2.5, 5 μM; 24, 48 h) induces apoptosis of FLT3-ITD-positive AML cells in a concentration and time-dependent manner[1].Wu-5 (5 μM; 24 h) induces FLT3-ITD degradation by the proteasome pathway[1].

References:
[1]. Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2630378-05-9
Molecular Formula
C15H13NO7S
Molecular Weight
351.33
Solubility
DMSO : 25 mg/mL (71.16 mM; ultrasonic and warming and heat to 60°C)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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