Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) , most likely by binding to plasma membrane phosphoglycoprotein to prevent drug efflux. Andrastin A inhibits survival of Caco-2 cells with an IC50 of >50 μg/ml.
Andrastin A
Catalog No.: GC42806Purity:>95.00%Synonyms: NSC 697452
Andrastin A is a meroterpenoid farnesyltransferase inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 174232-42-9
500μgIn Stock
$310.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 500μg | $310.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>95.00%Appearance:A solid
Chemical Properties
CAS No.
174232-42-9
Synonyms
NSC 697452
SMILES
CC1=C[C@]2([H])[C@]([C@@](C(C3C)=O)(C(OC)=O)[C@]1(C)C3=O)(C)CC[C@]4([H])C(C)(C)[C@@H](OC(C)=O)CC[C@]42C=O
Molecular Formula
C28H38O7
Molecular Weight
486.6
Solubility
DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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