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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Sodium Channel

Sodium channel are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell plasma membrane.

Products for  Sodium Channel

  1. Cat.No. Product Name Information
  2. GC45985 (±)-Indoxacarb A broad-spectrum insecticide (±)-Indoxacarb Chemical Structure
  3. GC30933 (+)-Kavain

    An Analytical Reference Standard

     (+)-Kavain Chemical Structure
  4. GC34952 (-)-Sparteine sulfate pentahydrate (-)-Sparteine sulfate pentahydrate Chemical Structure
  5. GC62739 (R)-Funapide (R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. (R)-Funapide Chemical Structure
  6. GC35108 3-Deoxyaconitine 3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator. 3-Deoxyaconitine Chemical Structure
  7. GC42327 4,9-Anhydrotetrodotoxin

    4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes).

     4,9-Anhydrotetrodotoxin Chemical Structure
  8. GC35147 5-(N,N-Hexamethylene)-amiloride An amiloride derivative with diverse biological activities 5-(N,N-Hexamethylene)-amiloride Chemical Structure
  9. GC65593 6-Benzoylheteratisine 6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine. 6-Benzoylheteratisine Chemical Structure
  10. GC14481 A 887826 voltage-dependent Nav1.8 sodium channel blocker A 887826 Chemical Structure
  11. GC15701 A-803467 NaV1.8 channel blocker,potent and selective A-803467 Chemical Structure
  12. GC35273 Ajmaline Ajmaline Chemical Structure
  13. GC30917 AM-2099 AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7. AM-2099 Chemical Structure
  14. GC15458 Ambroxol HCl Ambroxol HCl (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol HCl Chemical Structure
  15. GC31431 Amiloride (MK-870) Amiloride (MK-870) (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride (MK-870) Chemical Structure
  16. GC17853 Amiloride HCl Amiloride HCl (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride HCl Chemical Structure
  17. GC12051 Amiloride HCl dihydrate Amiloride HCl dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride HCl dihydrate Chemical Structure
  18. GC13723 Amitriptyline HCl Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl Chemical Structure
  19. GC18203 Annonacin Annonacin is a potent and lipophilic acetogenin from A. Annonacin Chemical Structure
  20. GC65272 APETx2 TFA APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 TFA Chemical Structure
  21. GC63799 AZ194 AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 Chemical Structure
  22. GC11693 Benzamil hydrochloride

    Na+/Ca2+ exhanger (NCX) inhibitor

     Benzamil hydrochloride Chemical Structure
  23. GC13125 Benzocaine Sodium channel inhibitor Benzocaine Chemical Structure
  24. GC25134 Benzocaine hydrochloride Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. Benzocaine hydrochloride Chemical Structure
  25. GC34486 BI 01383298 An NaCT inhibitor BI 01383298 Chemical Structure
  26. GC34492 BI-9627 An NHE1 inhibitor BI-9627 Chemical Structure
  27. GC60642 Bifenthrin A synthetic pyrethroid insecticide Bifenthrin Chemical Structure
  28. GC64658 Bliretrigine Bliretrigine is a sodium channel blocker. Bliretrigine Chemical Structure
  29. GC42976 Brevetoxin B Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B Chemical Structure
  30. GC35568 Bulleyaconitine A Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels. Bulleyaconitine A Chemical Structure
  31. GC12410 Bupivacaine HCl Bupivacaine HCl is a NMDA receptor inhibitor. Bupivacaine HCl Chemical Structure
  32. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels Carbamazepine Chemical Structure
  33. GC17842 CARIPORIDE Potent NHE inhibitor CARIPORIDE Chemical Structure
  34. GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine Chlorpromazine D6 hydrochloride Chemical Structure
  35. GC14216 Chlorpromazine HCl

    dopamine receptor antagonist

     Chlorpromazine HCl Chemical Structure
  36. GC16182 Co 102862 voltage-gated sodium channel blocker Co 102862 Chemical Structure
  37. GC47155 Cyfluthrin A pyrethroid insecticide Cyfluthrin Chemical Structure
  38. GC15915 Dibucaine Local anesthetic Dibucaine Chemical Structure
  39. GC16696 Dibucaine (Cinchocaine) HCl Sodium channel inhibitor Dibucaine (Cinchocaine) HCl Chemical Structure
  40. GC35860 Dibucaine hydrochloride Dibucaine hydrochloride Chemical Structure
  41. GC38484 Dimethyl lithospermate B Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B Chemical Structure
  42. GC43478 Disopyramide Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. Disopyramide Chemical Structure
  43. GC35903 DSP-2230 DSP-2230 is a selective Nav1.7/Nav1.8 blocker. DSP-2230 Chemical Structure
  44. GC15893 EIPA

    EIPA inhibited TRPP3-mediated Ca2+-activated currents with IC50 values of 10.5 µM.

     EIPA Chemical Structure
  45. GC35970 EIPA hydrochloride

    EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM.

     EIPA hydrochloride Chemical Structure
  46. GC30063 Eleclazine hydrochloride (GS 6615 hydrochloride) Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride (GS 6615 hydrochloride) Chemical Structure
  47. GC35993 Eniporide hydrochloride Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor. Eniporide hydrochloride Chemical Structure
  48. GC13809 Eslicarbazepine acetate antiepileptic drug Eslicarbazepine acetate Chemical Structure
  49. GC15824 Ethyl 3-Aminobenzoate (methanesulfonate) Ethyl 3-Aminobenzoate (methanesulfonate) (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. Ethyl 3-Aminobenzoate (methanesulfonate) Chemical Structure
  50. GC38389 Evenamide Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 ?M) for the research of schizophrenia. Evenamide Chemical Structure
  51. GC65416 Flecainide Flecainide is a potent and orally active antiarrhythmic agent. Flecainide Chemical Structure
  52. GC15823 Flecainide acetate An inhibitor of cardiac late sodium current Flecainide acetate Chemical Structure
  53. GC65150 Flecainide hydrochloride Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride Chemical Structure
  54. GC33895 FR183998 free base FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. FR183998 free base Chemical Structure
  55. GC30628 Funapide (TV 45070) Funapide (TV 45070) (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. Funapide (TV 45070) Chemical Structure
  56. GC64206 GDC-0310 GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7. GDC-0310 Chemical Structure
  57. GN10799 Ginsenoside Rg3 Ginsenoside Rg3 Chemical Structure
  58. GC67949 GNE-0439 GNE-0439 Chemical Structure
  59. GC31065 GNE-131 GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. GNE-131 Chemical Structure
  60. GC36169 GNE-616 GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain. GNE-616 Chemical Structure
  61. GC10830 GS967 inhibitor of cardiac late sodium current GS967 Chemical Structure
  62. GC10234 GSK1014802(CNV1014802) GSK1014802(CNV1014802) (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. GSK1014802(CNV1014802) Chemical Structure
  63. GC50707 GX 201 GX 201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7. GX 201 Chemical Structure
  64. GC39792 Halazone Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 ?M. Halazone Chemical Structure
  65. GC65531 Hardwickiic acid Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid Chemical Structure
  66. GC12806 Huwentoxin IV NaV1.7 channel blocker Huwentoxin IV Chemical Structure
  67. GC15860 Ibutilide Fumarate Class III antiarrhythmic agent Ibutilide Fumarate Chemical Structure
  68. GC17395 ICA 121431 human NaV1.3 and NaV1.1 channels inhibitor ICA 121431 Chemical Structure
  69. GC10836 Jingzhaotoxin III NaV1.5 channels blocker Jingzhaotoxin III Chemical Structure
  70. GC16786 KC 12291 hydrochloride voltage-gated sodium channel blocker KC 12291 hydrochloride Chemical Structure
  71. GC14764 Lamotrigine 5-HT inhibitor， sodium channel blocker Lamotrigine Chemical Structure
  72. GC64113 Lamotrigine-13C3,d3 Lamotrigine-13C3,d3 Chemical Structure
  73. GC15978 Levobupivacaine HCl Levobupivacaine HCl ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local anaesthetic. Levobupivacaine HCl Chemical Structure
  74. GC13505 Licarbazepine voltage-gated sodium channel blocker Licarbazepine Chemical Structure
  75. GC17608 Lidocaine Anasthetic and class Ib antiarrhythmic agent Lidocaine Chemical Structure
  76. GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) Lidocaine hydrochloride (Lignocaine hydrochloride) (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride (Lignocaine hydrochloride) Chemical Structure
  77. GC61594 Lu AE98134 Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 Chemical Structure
  78. GC63063 Mebeverine hydrochloride Mebeverine hydrochloride Chemical Structure
  79. GC41540 Mepivacaine Mepivacaine is an analytical reference standard that is categorized as an anesthetic. Mepivacaine Chemical Structure
  80. GC10224 Mepivacaine HCl Mepivacaine HCl binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. Mepivacaine HCl Chemical Structure
  81. GC34665 Metaflumizone Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker. Metaflumizone Chemical Structure
  82. GC61046 Methocarbamol D5 An internal standard for the quantification of methocarbamol Methocarbamol D5 Chemical Structure
  83. GC11069 Meticrane Peripheral-type benzodiazepine receptor (PBR) inhibitor Meticrane Chemical Structure
  84. GC44189 Mexiletine (hydrochloride) Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. Mexiletine (hydrochloride) Chemical Structure
  85. GC39618 Mexiletine D6 hydrochloride Mexiletine D6 hydrochloride (KOE-1173-d6 hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine D6 hydrochloride Chemical Structure
  86. GC36648 Moricizine Moricizine Chemical Structure
  87. GC31200 Myomodulin

    Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.

     Myomodulin Chemical Structure
  88. GC65231 N-Bromoacetamide N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation. N-Bromoacetamide Chemical Structure
  89. GC50071 NAV 26 Selective Nav1.7 channel blocker NAV 26 Chemical Structure
  90. GC61110 Nav1.1 activator 1 Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6. Nav1.1 activator 1 Chemical Structure
  91. GC36697 Nav1.7 inhibitor Nav1.7 inhibitor (compound II), a sulfonamide, is a potent Nav1.7 inhibitor. Nav1.7 inhibitor Chemical Structure
  92. GC36698 NaV1.7 inhibitor-1 NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC50 of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5. NaV1.7 inhibitor-1 Chemical Structure
  93. GC31002 Nav1.7-IN-2 Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. Nav1.7-IN-2 Chemical Structure
  94. GC65320 Nav1.7-IN-3 Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Nav1.7-IN-3 Chemical Structure
  95. GC64072 NBI-921352 NBI-921352 Chemical Structure
  96. GC31302 NHE3-IN-1 NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1. NHE3-IN-1 Chemical Structure
  97. GC63108 NHE3-IN-2 NHE3-IN-2 is a Na+/H+ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin). NHE3-IN-2 Chemical Structure
  98. GC31216 Nicainoprol (RU-42924) Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent. Nicainoprol (RU-42924) Chemical Structure
  99. GC39719 Nigericin

    K+/H+ ionophore,promoting K+/H+ exchange across mitochondrial membrane

     Nigericin Chemical Structure
  100. GC50299 OD1 Potent hNav1.4, rNav1.6 and rNav1.7 channel activator OD1 Chemical Structure
  101. GC10500 Oxcarbazepine BTX inhibitor Oxcarbazepine Chemical Structure

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