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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Sodium Channel

Sodium channel are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell plasma membrane.

Products for  Sodium Channel

  1. Cat.No. Product Name Information
  2. GC72133 &#181-Conotoxin-CnIIIC acetate µ-Conotoxin-CnIIIC acetate, a 22-residue conopeptide, is a potent antagonist of the voltage-gated NaV1.4 sodium channel with an IC50 of 1.3 nM acting at the neuromuscular junction. µ-Conotoxin-CnIIIC acetate Chemical Structure
  3. GC45985 (±)-Indoxacarb

    DPX-JW062, DPX-MP062

     A broad-spectrum insecticide (±)-Indoxacarb Chemical Structure
  4. GC30933 (+)-Kavain

    Kawain, NSC 112162

    An Analytical Reference Standard

     (+)-Kavain Chemical Structure
  5. GC34952 (-)-Sparteine sulfate pentahydrate (-)-Sparteine sulfate pentahydrate Chemical Structure
  6. GC62739 (R)-Funapide

    (R)-TV 45070; (R)-XEN402

     (R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. (R)-Funapide Chemical Structure
  7. GC70292 (Rac)-AMG8379 (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. (Rac)-AMG8379 Chemical Structure
  8. GC73762 (S)-LTGO-33 (S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S)-LTGO-33 Chemical Structure
  9. GC35108 3-Deoxyaconitine 3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator. 3-Deoxyaconitine Chemical Structure
  10. GC42327 4,9-Anhydrotetrodotoxin

    4,9-anhydro-TTX

    4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes).

     4,9-Anhydrotetrodotoxin Chemical Structure
  11. GC35147 5-(N,N-Hexamethylene)-amiloride

    HMA

     An amiloride derivative with diverse biological activities 5-(N,N-Hexamethylene)-amiloride Chemical Structure
  12. GC65593 6-Benzoylheteratisine 6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine. 6-Benzoylheteratisine Chemical Structure
  13. GC14481 A 887826 voltage-dependent Nav1.8 sodium channel blocker A 887826 Chemical Structure
  14. GC15701 A-803467 NaV1.8 channel blocker,potent and selective A-803467 Chemical Structure
  15. GC68591 ABBV-318

    ABBV-318 is an effective Nav1.7/Nav1.8 blocker, with IC50 values of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8 inhibition, respectively. ABBV-318 can be used in pain-related research.

     ABBV-318 Chemical Structure
  16. GC35273 Ajmaline

    NSC 15627

     Ajmaline Chemical Structure
  17. GC30917 AM-2099 AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7. AM-2099 Chemical Structure
  18. GC15458 Ambroxol HCl

    NA 872

     Ambroxol HCl (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol HCl Chemical Structure
  19. GC31431 Amiloride (MK-870) Amiloride (MK-870) is a selective T-type calcium channel blocker and an inhibitor of epithelial sodium channels (ENaC) and urokinase-type plasminogen activator receptor (uTPA), Ki=7 µM. It is also polycystin-2 (PC2;TRPP2) channel blocker. Amiloride (MK-870) Chemical Structure
  20. GC17853 Amiloride HCl

    MK-870

     Amiloride HCl (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride HCl Chemical Structure
  21. GC12051 Amiloride HCl dihydrate Amiloride HCl dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride HCl dihydrate Chemical Structure
  22. GC13723 Amitriptyline HCl

    NIH 10794, Ro 4-1575

     Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl Chemical Structure
  23. GC18203 Annonacin Annonacin is a potent and lipophilic acetogenin from A. Annonacin Chemical Structure
  24. GC72240 Anthopleurin-A TFA Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA Chemical Structure
  25. GC65272 APETx2 TFA APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 TFA Chemical Structure
  26. GC72125 ATX-II TFA ATX-II TFA is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA Chemical Structure
  27. GC63799 AZ194 AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 Chemical Structure
  28. GC11693 Benzamil hydrochloride

    Na+/Ca2+ exhanger (NCX) inhibitor

     Benzamil hydrochloride Chemical Structure
  29. GC13125 Benzocaine

    Ethyl 4-Aminobenzoate, H-4-Abz-OEt, NSC 4688, NSC 41531

     Sodium channel inhibitor Benzocaine Chemical Structure
  30. GC25134 Benzocaine hydrochloride

    Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride

     Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. Benzocaine hydrochloride Chemical Structure
  31. GC68749 Benzocaine-(ethyl-d5)

    Benzocaine-(ethyl-d5) is the deuterated form of Benzocaine. Benzocaine acts as a co-receptor for voltage-gated Na+ channels, with an IC50 value of 0.8 mM measured at +30 mV.

     Benzocaine-(ethyl-d5) Chemical Structure
  32. GC34486 BI 01383298 An NaCT inhibitor BI 01383298 Chemical Structure
  33. GC34492 BI-9627 An NHE1 inhibitor BI-9627 Chemical Structure
  34. GC60642 Bifenthrin

    (±)-Bifenthrin

     A synthetic pyrethroid insecticide Bifenthrin Chemical Structure
  35. GC64658 Bliretrigine Bliretrigine is a sodium channel blocker. Bliretrigine Chemical Structure
  36. GC42976 Brevetoxin B

    Brevetoxin 2, BTX-B, GbTx-2, PbTx-2

    Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates.

     Brevetoxin B Chemical Structure
  37. GC35568 Bulleyaconitine A Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels. Bulleyaconitine A Chemical Structure
  38. GC12410 Bupivacaine HCl

    AH 2250, (±)-1-butyl-2′,6′-Pipecoloxylidide

     Bupivacaine HCl is a NMDA receptor inhibitor. Bupivacaine HCl Chemical Structure
  39. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels Carbamazepine Chemical Structure
  40. GC17842 CARIPORIDE

    HOE 642

     Potent NHE inhibitor CARIPORIDE Chemical Structure
  41. GC71961 Cevadine Cevadine is a voltage-sensitive sodium channel agonist. Cevadine Chemical Structure
  42. GC30280 Chlorpromazine D6 hydrochloride

    CPZ-d6

     An internal standard for the quantification of chlorpromazine Chlorpromazine D6 hydrochloride Chemical Structure
  43. GC14216 Chlorpromazine HCl

    CPZ

     Chlorpromazine HCl is an orally effective, blood-brain-permeable phenothiazine antipsychotic that can effectively antagonize D2 dopamine receptors and 5-HT2A and has a strong sedative effect. Chlorpromazine HCl Chemical Structure
  44. GC72296 Cn2 toxin TFA Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin TFA Chemical Structure
  45. GC16182 Co 102862

    V 102862

     voltage-gated sodium channel blocker Co 102862 Chemical Structure
  46. GC74397 Crotamine TFA Crotamine TFA is a Na+ channel modulator. Crotamine TFA Chemical Structure
  47. GC47155 Cyfluthrin

    β-Cyfluthrin

     A pyrethroid insecticide Cyfluthrin Chemical Structure
  48. GC15915 Dibucaine

    NSC 159055

     Local anesthetic Dibucaine Chemical Structure
  49. GC16696 Dibucaine (Cinchocaine) HCl Sodium channel inhibitor Dibucaine (Cinchocaine) HCl Chemical Structure
  50. GC35860 Dibucaine hydrochloride Dibucaine hydrochloride Chemical Structure
  51. GC38484 Dimethyl lithospermate B Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B Chemical Structure
  52. GC43478 Disopyramide

    (±)-Disopyramide, Ritmilen, SC-7031

     Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. Disopyramide Chemical Structure
  53. GC35903 DSP-2230 DSP-2230 is a selective Nav1.7/Nav1.8 blocker. DSP-2230 Chemical Structure
  54. GC15893 EIPA

    L-593,754, MH 12-43, 5-(N-ethyl-N-isopropyl)-Amiloride

     EIPA inhibited TRPP3-mediated Ca2+-activated currents with IC50 values of 10.5 µM. EIPA Chemical Structure
  55. GC35970 EIPA hydrochloride

    L593754 hydrochloride; MH 12-43 hydrochloride

    EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM.

     EIPA hydrochloride Chemical Structure
  56. GC30063 Eleclazine hydrochloride (GS 6615 hydrochloride)

    GS 6615 hydrochloride

     Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride (GS 6615 hydrochloride) Chemical Structure
  57. GC35993 Eniporide hydrochloride

    EMD-96785 hydrochloride

     Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor. Eniporide hydrochloride Chemical Structure
  58. GC13809 Eslicarbazepine acetate

    BIA 2-093

     antiepileptic drug Eslicarbazepine acetate Chemical Structure
  59. GC15824 Ethyl 3-Aminobenzoate (methanesulfonate)

    Ethyl m-Aminobenzoate, NSC 93790, Tricaine methanesulfonate, MS-222

     Ethyl 3-Aminobenzoate (methanesulfonate) (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. Ethyl 3-Aminobenzoate (methanesulfonate) Chemical Structure
  60. GC38389 Evenamide

    NW-3509

     Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 ?M) for the research of schizophrenia. Evenamide Chemical Structure
  61. GC65416 Flecainide Flecainide is a potent and orally active antiarrhythmic agent. Flecainide Chemical Structure
  62. GC15823 Flecainide acetate An inhibitor of cardiac late sodium current Flecainide acetate Chemical Structure
  63. GC65150 Flecainide hydrochloride Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride Chemical Structure
  64. GC71513 Flecainide-d4 acetate Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide-d4 acetate Chemical Structure
  65. GC33895 FR183998 free base FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. FR183998 free base Chemical Structure
  66. GC30628 Funapide (TV 45070)

    TV 45070; XEN402

     Funapide (TV 45070) (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. Funapide (TV 45070) Chemical Structure
  67. GC64206 GDC-0310 GDC-0310 is a selective acylsulfonamide voltage-gated sodium channel 1.7 (NaV1.7) inhibitor with an IC50 value of 0.6nM. GDC-0310 Chemical Structure
  68. GN10799 Ginsenoside Rg3

    20(S)-Propanaxadiol

     Ginsenoside Rg3 Chemical Structure
  69. GC67949 GNE-0439 GNE-0439 Chemical Structure
  70. GC31065 GNE-131 GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. GNE-131 Chemical Structure
  71. GC36169 GNE-616 GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain. GNE-616 Chemical Structure
  72. GC10830 GS967 inhibitor of cardiac late sodium current GS967 Chemical Structure
  73. GC10234 GSK1014802(CNV1014802)

    GSK-1014802; CNV1014802

     GSK1014802(CNV1014802) (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. GSK1014802(CNV1014802) Chemical Structure
  74. GC50707 GX 201 GX 201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7. GX 201 Chemical Structure
  75. GC39792 Halazone Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 ?M. Halazone Chemical Structure
  76. GC65531 Hardwickiic acid

    (-)-Hardwikiic acid

     Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid Chemical Structure
  77. GC12806 Huwentoxin IV NaV1.7 channel blocker Huwentoxin IV Chemical Structure
  78. GC15860 Ibutilide Fumarate

    U-70226E

     Class III antiarrhythmic agent Ibutilide Fumarate Chemical Structure
  79. GC17395 ICA 121431 human NaV1.3 and NaV1.1 channels inhibitor ICA 121431 Chemical Structure
  80. GC74411 Iota-conotoxin RXIA TFA Iota-conotoxin RXIA (TFA) is an agonist of voltage-gated sodium ion channels NaV1.2, 1.6 and 1.7. Iota-conotoxin RXIA TFA Chemical Structure
  81. GC10836 Jingzhaotoxin III NaV1.5 channels blocker Jingzhaotoxin III Chemical Structure
  82. GC16786 KC 12291 hydrochloride voltage-gated sodium channel blocker KC 12291 hydrochloride Chemical Structure
  83. GC74052 KGP-25 KGP-25 is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8), which can be used for analgesia by targeting Nav1.8 in the peripheral nervous system (PNS). KGP-25 Chemical Structure
  84. GC14764 Lamotrigine

    BW 430C, LTG

     5-HT inhibitor， sodium channel blocker Lamotrigine Chemical Structure
  85. GC64113 Lamotrigine-13C3,d3 Lamotrigine-13C3,d3 Chemical Structure
  86. GC15978 Levobupivacaine HCl

    (S)-(-)-Bupivacaine

     Levobupivacaine HCl ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local anaesthetic. Levobupivacaine HCl Chemical Structure
  87. GC13505 Licarbazepine

    BIA 2-005, 10,11-dihydro-10-hydroxy CBZ, 10,11-hydroxy-10,11 Dihydrocarbamezer, GP 47779, Licarbazepine

     voltage-gated sodium channel blocker Licarbazepine Chemical Structure
  88. GC70293 Licarbazepine-d3 Licarbazepine-d3 is the deuterium labeled Licarbazepine . Licarbazepine-d3 Chemical Structure
  89. GC17608 Lidocaine

    NSC 40030

     Anasthetic and class Ib antiarrhythmic agent Lidocaine Chemical Structure
  90. GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) Lidocaine hydrochloride (Lignocaine hydrochloride) (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride (Lignocaine hydrochloride) Chemical Structure
  91. GC72793 Losigamone

    AO-33; (±)-Losigamone; LSG

     Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone Chemical Structure
  92. GC73761 LTGO-33 LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 Chemical Structure
  93. GC61594 Lu AE98134 Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 Chemical Structure
  94. GC72780 Lubeluzole dihydrochloride Lubeluzole (didrochloride) is a neuroprotective agent which blockades neuronal voltage-gated sodium channels. Lubeluzole dihydrochloride Chemical Structure
  95. GC63063 Mebeverine hydrochloride Mebeverine hydrochloride Chemical Structure
  96. GC41540 Mepivacaine Mepivacaine is an analytical reference standard that is categorized as an anesthetic. Mepivacaine Chemical Structure
  97. GC10224 Mepivacaine HCl Mepivacaine HCl binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. Mepivacaine HCl Chemical Structure
  98. GC34665 Metaflumizone Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker. Metaflumizone Chemical Structure
  99. GC61046 Methocarbamol D5

    AHR 85-d5, Guaiacol Glyceryl Ether Carbamate-d5, Guaiphenesin Carbamate-d5

     An internal standard for the quantification of methocarbamol Methocarbamol D5 Chemical Structure
  100. GC71633 Methocarbamol-d3 Methocarbamol-d3 is the deuterium labeled Methocarbamol. Methocarbamol-d3 Chemical Structure
  101. GC11069 Meticrane Peripheral-type benzodiazepine receptor (PBR) inhibitor Meticrane Chemical Structure

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