CAY10575 (Synonyms: IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1) |
| Catalog No.GC43176 |
CAY10575 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 916985-21-2
Sample solution is provided at 25 µL, 10mM.
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The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 µM.
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