Cerebellin TFA |
Catalog No.GC79490
One-Click Copy Product Info
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Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vivo, Cerebellin (1-1000 nM; intrarenal adrenal perfusion; continuous administration during sample collection) TFA potently stimulates norepinephrine release from perfused rat adrenal glands via an adenylate cyclase/PKA-dependent pathway[1]. Cerebellin (0.5-1.5 nmol/100 g body weight; subcutaneous injection; single bolus) TFA acts as an insulin inhibitor in healthy female Wistar rats[2].
In Vitro, Cerebellin (1-100 nM; 10-30 min) TFA potently stimulates the production of norepinephrine and cyclic adenosine monophosphate in rat adrenal medullary tissues via an adenylate cyclase/PKA-dependent pathway[1]. Cerebellin (1-100 nM; 90 min) TFA inhibits glucose-stimulated insulin secretion from isolated rat islets[2]. Cerebellin (100 nM-1 μM; 1 hour) TFA inhibits glucose/Exendin-4 -stimulated insulin secretion in INS-1 cells[2]. Cerebellin (10 nM-1 μM; 5 min) TFA reduces Forskolin -induced cAMP accumulation in INS-1 cells in a concentration-dependent manner[2]. Cerebellin (100 nM) TFA irreversibly reduces the intracellular free calcium concentration in INS-1 cells[2].
References:
[1]. Albertin G, et al. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Neuropeptides. 2000;34(1):7-11.
[2]. Strowski MZ, et al. Insulinostatic activity of cerebellin--evidence from in vivo and in vitro studies in rats. Regul Pept. 2009;157(1-3):19-24.
[3]. Slemmon JR, et al. Cerebellin: a quantifiable marker for Purkinje cell maturation. Proc Natl Acad Sci U S A. 1985;82(20):7145-7148.
[4]. Mugnaini E, et al. The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain. Proc Natl Acad Sci U S A. 1987;84(23):8692-8696.
| Cas No. | SDF | ||
| Formula | C69H113N23O23·xC2HF3O2 | M.Wt | 1632.78 |
| Solubility | Storage | Sealed storage, away from moisture | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 612.5 μL | 3.0623 mL | 6.1245 mL |
| 5 mM | 122.5 μL | 612.5 μL | 1.2249 mL |
| 10 mM | 61.2 μL | 306.2 μL | 612.5 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)