2-chloro Palmitic Acid (Synonyms: 2-ClHA, 2-CLPA) |
| Katalog-Nr.GC42135 |
2-ChlorpalmitinsÄure, ein entzÜndlicher Lipidmediator, stÖrt die Proteinpalmitylierung, induziert ER-Stressmarker, reduziert den ER-ATP-Gehalt und aktiviert die Transkription und Sekretion von IL-6 sowie IL-8.2-ChlorpalmitinsÄure stÖrt die Mitochondrien Membranpotential und induziert die Procaspase-3- und PARP-Spaltung. 2-ChlorpalmitinsÄure kann die Blut-Hirn-Schranke (BBB) Überwinden und beeintrÄchtigt ER- und Mitochondrienfunktionen in der Endothelzelllinie hCMEC/D3 des menschlichen Gehirns.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19117-92-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *