TIC10 isomer (Synonyms: ONC201 isomer) |
Katalog-Nr.GC10350
One-Click Copy Product Info
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TIC10-Isomer ist das Isomer von TIC10.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41276-02-2
Sample solution is provided at 25 µL, 10mM.
TIC10 isomer is the analogue of TIC10/ONC201[1]. The TIC10 isomer can be used as a model compound to analyze the active structure and optimize the production route of TIC10[2]. TIC10 isomer can be used as an internal reference to develop new nuclear magnetic resonance (NMR) methods for characterizing related compounds[3].
References:
[1] Greer Y E, Lipkowitz S. TIC10/ONC201: a bend in the road to clinical development[J]. Oncoscience, 2015, 2(2): 75.
[2] Jacob N T, Lockner J W, Kravchenko V V, et al. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL[J]. Angewandte Chemie, 2014, 126(26): 6746-6749.
[3] Oguadinma P, Bilodeau F, LaPlante S R. NMR strategies to support medicinal chemistry workflows for primary structure determination[J]. Bioorganic & medicinal chemistry letters, 2017, 27(2): 242-247.
| Cas No. | 41276-02-2 | SDF | |
| Überlieferungen | ONC201 isomer | ||
| Chemical Name | 7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one | ||
| Canonical SMILES | O=C1C(CN(CC2=CC=CC=C2)CC3)=C3N(CC4=CC=CC=C4C)C5=NCCN15 | ||
| Formula | C24H26N4O | M.Wt | 386.49 |
| Löslichkeit | ≥ 6.43mg/mL in DMSO with gentle warming | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5874 mL | 12.9369 mL | 25.8739 mL |
| 5 mM | 517.5 μL | 2.5874 mL | 5.1748 mL |
| 10 mM | 258.7 μL | 1.2937 mL | 2.5874 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)