Omeprazole sulfone (Synonyms: OMEP sulfone, OMP sulfone, OMZ sulfone) |
Catalog No.GC11155
One-Click Copy Product Info
|
Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 88546-55-8
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole [1]. The Proton Pump Inhibitor, Omeprazole, is a metabolism-dependent inhibitor of CYP2C19 with a relatively low incidence of adverse events and pharmacokinetic drug-drug interactions (DDIs) [1]. Omeprazole sulfone is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and has been found in plasma [2]. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and lead to many clinically relevant diseases [3].
In vitro: Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes with an IC50 of 18 μM [1].
In vivo: Three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive CYP2C19 metabolizers (EM) and 672 nmol/l in the five subjects known to be poor CYP2C19 metabolizers (PM). The mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
References:
[1] Nebert D W, Russell D W. Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.
[2] bel A, Andersson T B, Antonsson M, et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes[J]. Drug Metabolism and Disposition, 2000, 28(8): 966-972.
[3] Nebert D W, Russell D W. Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.
[4] Bttiger Y. Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4[J]. European journal of clinical pharmacology, 2006, 62(8): 621-625.
| Cas No. | 88546-55-8 | SDF | |
| Synonyms | OMEP sulfone, OMP sulfone, OMZ sulfone | ||
| Chemical Name | 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole | ||
| Canonical SMILES | COC1=CC=C2C(N=C(S(CC3=C(C)C(OC)=C(C)C=N3)(=O)=O)N2)=C1 | ||
| Formula | C17H19N3O4S | M.Wt | 361.4 |
| Solubility | ≤5mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.767 mL | 13.8351 mL | 27.6702 mL |
| 5 mM | 553.4 μL | 2.767 mL | 5.534 mL |
| 10 mM | 276.7 μL | 1.3835 mL | 2.767 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)