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Dynamin inhibitory peptide

Catalog No.GP10022

Dynamin inhibitory peptide Chemical Structure

Peptide inhibitor of GTPase dynamin

Size Price Stock Qty
1mg
$83.00
In stock
5mg
$257.00
In stock
10mg
$433.00
In stock
25mg
$564.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Background

Dynamin Inhibitory Peptide is a peptide (Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro) inhibitor of the GTPase dynamin.

Dynamin is a 100-kDa large GTPase that functions to tabulate membranes and liberate nascent vesicles from the Golgi apparatus and plasma membrane. Dynamin also plays a role in many processes including division of organelles,cytokinesis and microbial pathogen resistance.

Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

References:
1. McNiven, M. A., Cao, H., Pitts, K. R. & Yoon, Y. (2000) Trends Biochem. Sci. 25, 115-120.
2. Hinshaw, J. E. (2000) Annu. Rev. Cell Dev. Biol 16, 483-519.
3. Thoms S, Erdmann R (Oct 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169-81.
4. Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419-25.
5. Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972-7.
6. Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302-7.

Chemical Properties

Cas No. 251634-21-6 SDF
Synonyms Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro
Chemical Name Dynamin inhibitory peptide
Canonical SMILES CC(C)C(C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)N2CCCC2C(=O)NC(CC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C(CCC(=O)N)N
Formula C47H80N18O14 M.Wt 1121.26
Solubility ≥ 112.1mg/mL in DMSO Storage Desiccate at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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