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Factor Xa

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Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Products Related to Factor Xa(59)

  • GC17799 structure
    GC17799Betrixaban
    CAS: 330942-05-7
    Purity: >98.00%

    Factor Xa inhibitor

  • GC11101 structure
    GC111015-R-Rivaroxaban
    CAS: 865479-71-6
    Purity: >99.50%
  • GC11644 structure
    GC11644Edoxaban
    CAS: 480449-70-5
    Purity: >98.00%
  • GC12839 structure
    GC12839Edoxaban tosylate monohydrate
    CAS: 1229194-11-9
    Purity: >99.50%

    A potent inhibitor of Factor Xa

  • GC13130 structure
    GC13130Apixaban
    CAS: 503612-47-3
    Purity: >99.50%

    An inhibitor of Factor Xa

  • GC13683 structure
    GC13683Rivaroxaban
    CAS: 366789-02-8
    Purity: >99.50%

    A selective inhibitor of Factor Xa

  • GC13711 structure
    GC13711Gabexate mesylate
    CAS: 56974-61-9
    Purity: >98.00%

    A serine protease inhibitor

  • GC15757 structure
    GC15757Ozagrel
    CAS: 82571-53-7
    Purity: >99.50%

    A selective inhibitor of TXA synthase

  • GC17726 structure
    GC17726Otamixaban
    CAS: 193153-04-7
    Purity: >98.50%
  • GC18452 structure
    GC184523,4-Dichloroisocoumarin
    CAS: 51050-59-0
    Purity: >99.50%

    A serine protease inhibitor

  • GC19766 structure
    GC19766Heparin sodium salt (MW 15kDa)
    CAS: 9041-08-1

    A polymer of Heparin with the molecular weight of 15kD

  • GC19839 structure
    GC19839Trypsin inhibitor(soybean) (≥4000 BAEE Units/mg)
    CAS: 9035-81-8

    Trypsin inhibitor(soybean) is a trypsin inhibitor with an IC 50 of 19 µM. It can also inhibit chymotrypsin with an IC 50 of 14.3µM.

  • GC25137 structure
    GC25137Betrixaban maleate
    CAS: 936539-80-9
    Purity: >98%

    Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.

  • GC32567 structure
    GC32567RWJ-445167 (3DP-10017)
    CAS: 226566-43-4
    Purity: >98%

    RWJ-445167 (3DP-10017) (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

  • GC32614 structure
    GC32614BMS-654457
    CAS: 1004551-41-0
    Purity: >98%

    BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.

  • GC35536 structure
    GC35536BMS-962212
    CAS: 1430114-34-3
    Purity: >98%

    BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor .

  • GC35962 structure
    GC35962Edoxaban tosylate
    CAS: 480449-71-6
    Purity: >99.00%

    Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase.

  • GC36092 structure
    GC36092FXIa-IN-1
    CAS: 1803271-50-2
    Purity: >98%

    FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.

  • GC36831 structure
    GC36831Ozagrel sodium
    CAS: 189224-26-8
    Purity: >99.50%

    Ozagrel sodium (OKY-046 sodium) is a thromboxane A2 (TXA2) synthase inhibitor.

  • GC40529 structure
    GC405297-hydroxy Warfarin
    CAS: 17834-03-6
    Purity: >98%

    7-hydroxy Warfarin is a metabolite of (-)-warfarin, which is a more potent vitamin K antagonist than (+)-warfarin.

  • GC43696 structure
    GC43696Fondaparinux (sodium salt)
    CAS: 114870-03-0
    Purity: >98.00%

    Fondaparinux (sodium salt) is an antithrombin-dependent factor Xa inhibitor.

  • GC44966 structure
    GC44966Sucrose octasulfate (potassium salt)
    CAS: 73264-44-5
    Purity: >95.00%

    Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.

  • GC45620 structure
    GC45620Bromadiolone
    CAS: 28772-56-7
    Purity: 95.00%

    An anticoagulant rodenticide

  • GC46863 structure
    GC46863Apixaban-13C-d3
    CAS: 1261393-15-0
    Purity: >99.00%

    An internal standard for the quantification of apixaban