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Nigericin

Catalog No.GC39719

Ionophore K+/H+, favorisant l'échange de K+/H+ à travers la membrane mitochondriale.

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Nigericin Chemical Structure

Cas No.: 28380-24-7

Taille Prix Stock Qté
5mg
63,00 $US
En stock
10mg
91,00 $US
En stock
25mg
202,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 4 publications

Product Documents

Quality Control & SDS

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Background

Nigericin est un antibiotique dérivé de Streptomyces hygroscopicus qui agit comme un ionophore K+/H+, favorisant l'échange de K+/H+ à travers les membranes mitochondriales[1]. Nigericin peut être un activateur NLRP3 qui induit la libération d'IL-1β de manière dépendante du NALP3[2]. Nigericin déclenche l'éryptose, un effet parallèle à la formation de ROS et en partie dû à l'induction du stress oxydatif. Nigericin déclenche également l'apoptose[3].

References:
[1]. Zotova L, et al. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010 May 7;285(19):14399-414.
[2]. Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440(7081):228-32.
[3]. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9.

Chemical Properties

Cas No. 28380-24-7 SDF
Canonical SMILES C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O)=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@]4([H])O[C@](C)([C@]5([H])O[C@]([C@@]([C@H](C[C@H]6C)C)([H])O[C@@]6(O)CO)([H])C[C@@H]5C)CC4)C1
Formula C40H68O11 M.Wt 724.96
Solubility 1.2mg/mL in DMF, 20mg/mL in Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.3794 mL 6.8969 mL 13.7939 mL
5 mM 0.2759 mL 1.3794 mL 2.7588 mL
10 mM 0.1379 mL 0.6897 mL 1.3794 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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