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HIF

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Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.

Products Related to HIF(59)

  • GC32724 structure
    GC32724LW6 (HIF-1α inhibitor)
    CAS: 934593-90-5
    Purity: >98.00%

    LW6 is a hypoxia-inducing factor 1(HIF) inhibitor, which effectively inhibits HIF-1α accumulation by degrading HIF-1α, but does not affect HIF-1A mRNA level during hypoxia.

  • GC32876 structure
    GC32876SYP-5
    CAS: 1384268-04-5
    Purity: >99.50%

    A HIF-1 inhibitor

  • GC32945 structure
    GC32945THS-044
    CAS: 62054-67-5
    Purity: >98%

    THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.

  • GC32948 structure
    GC32948IDF-11774
    CAS: 1429054-28-3
    Purity: >98%

    IDF-11774 is an orally administered HIF-1α inhibitor, with an IC 50 value of 3.65μM.

  • GC33043 structure
    GC33043EL-102
    CAS: 1233948-61-2
    Purity: >99.50%

    EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer.

  • GC33170 structure
    GC33170ENMD-119 (ENMD 1198)
    CAS: 864668-87-1
    Purity: >98.50%

    ENMD-119 (ENMD 1198) (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-119 (ENMD 1198) is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.

  • GC33416 structure
    GC33416AFP464
    CAS: 468719-52-0
    Purity: >98%

    AFP464 (NSC710464 free base), is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

  • GC33634 structure
    GC33634Enarodustat (JTZ-951)
    CAS: 1262132-81-9
    Purity: >98.00%

    Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM.

  • GC34595 structure
    GC34595GN44028
    CAS: 1421448-26-1
    Purity: >98.00%

    GN44028 is a hypoxia-inducible factor (HIF)-1α inhibitor with an IC₅₀ value of 14nM.

  • GC35230 structure
    GC35230Acetylarenobufagin
    CAS: 184673-79-8
    Purity: >98%

    Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-I) modulator.

  • GC37034 structure
    GC37034PT2977
    CAS: 1672668-24-4
    Purity: >98.00%

    PT2977 is an orally active and selective HIF-2α inhibitor with an IC 50 of 9nM.

  • GC37066 structure
    GC37066Rac-PT2399
    CAS: 1672662-07-5
    Purity: >99.00%

    A potent and specific HIF-2α inhibitor

  • GC37801 structure
    GC37801TM6089
    CAS: 863421-32-3
    Purity: >98%

    TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia.

  • GC37889 structure
    GC37889VCE-004.8
    CAS: 1818428-24-8
    Purity: >98.00%

    VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist.

  • GC37966 structure
    GC37966ZINC13466751
    CAS: 117953-17-0
    Purity: >98.50%

    ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M.

  • GC38044 structure
    GC38044Fraxinellone
    CAS: 28808-62-0
    Purity: >99.50%
  • GC38767 structure
    GC38767Deoxyshikonin
    CAS: 43043-74-9
    Purity: >99.50%

    Deoxyshikonin is a natural product isolated from Lithospermum erythrorhizon Sieb with antitumor activity.

  • GC39146 structure
    GC39146HIF-1 inhibitor-1
    CAS: 2380261-53-8
    Purity: >98%

    An inhibitor of HIF-1 signaling

  • GC41625 structure
    GC41625Oroxylin A
    CAS: 480-11-5
    Purity: >98.00%

    Oroxylin A is an active flavonoid with anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer properties.

  • GC78962 structure
    GC78962MS1129
    Purity: >98%

    MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins.

  • GC79574 structure
    GC79574mCPX
    CAS: 1351572-56-9
    Purity: >98%

    mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX).

  • GC79669 structure
    GC79669PHD-1-IN-4
    CAS: 2009343-19-3
    Purity: >99.50%

    PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] .

  • GC79670 structure
    GC79670ZG-2686
    CAS: 1795110-22-3
    Purity: >98%

    ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM.

  • GC79671 structure
    GC79671HIF-IN-2
    CAS: 1040535-05-4
    Purity: >95.00%

    HIF-IN-2 is a HIF/HIF prolyl hydroxylase inhibitor.