Ubiquitination/ Proteasome

Rosolutamide (ASC-JM17) is an orally active Nrf1/Nrf2 activator.

Semaglutide- 13 C 6, 15 N TFA is the 13 C- and 15 N-labeled Semaglutide TFA.

SKLB-D18 is an orally active ERK1/2/ERK5 inhibitor, with an IC 50 of 38.69 nM and a K d of 126.9 nM against human ERK1, an IC 50 of 40.12 nM and a K d of 209.8 nM against ERK2, and an IC 50 of 59.72 nM and a K d of 468.2 nM against ERK5.

Sorafenib - 13 C,d 3 (Bay 43-9006- 13 C,d 3 ) is the 13 C, deuterated-labeled Sorafenib.

Spironolactone-d 3 is the deuterium labeled Spironolactone.

ST-539 is the inhibitor for deubiquitinase USP30 with IC 50 of 0.37 μM.

SYUIQ-5 is a G-quadruplex stabilizer.

Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor.

Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1] .

Thalidomide -5-methyl is the Thalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein.

Thalidomide-NH-amido-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1] .

Thalidomide-O-amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] . Thalidomide-O-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1] . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Thalidomide -piperazine hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a cereblon ligand based on Thalidomide and one linker.

Tigecycline (GAR-936) hydrate is a broad-spectrum glycylcycline antibiotic.

Trametinib-d 4 is the deuterium labeled Trametinib.

Troglitazone-d 4 is deuterium labeled Troglitazone.

UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC 50 value of 104 nM, displays 144- and 10-fold selectivity over β1c ( IC 50 =15 μM) and β5 subunit ( IC 50 =1 μM), respectivey [1] . UK-101 induces cell apoptosis and can be used for the study of prostate cancer [2] .

UP12 is an ATPase activity activator that activates the ATPase activity of valosin-containing protein (VCP), with an EC 50 of 1.24 μM.

UP158 enhances the activity of ATPase, and activates valosin-containing protein ( VCP ) with an EC 50 of 2.57 μM [1] .

UP163 enhances the activity of ATPase, and activates valosin-containing protein ( VCP ) with an EC 50 of 9.0 μM.

Valproic acid-d 14 (sodium) is deuterium labeled Valproic acid (sodium).

Valproic acid-d 4 -1 is the deuterium labeled Valproic acid.

Vinorelbine-d 3 (ditartrate) is the deuterium labeled Vinorelbine ditartrate.