CHNQD-00824 |
Catalog No.GC79871
One-Click Copy Product Info
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CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2222643-74-3
Sample solution is provided at 25 µL, 10mM.
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In Vivo, CHNQD-00824 (0-15 μM, from 24 to 48 h post-fertilization) causes cell death via DNA damage in Zebrafish[1]. CHNQD-00824 (1.25-5 μM, from day 3 to day 7 post-fertilization) inhibits DOX-induced liver-specific enlargement in zebrafish embryos in a dose-dependent manner[1].
In Vitro, CHNQD-00824 (72 h) exhibits potent inhibitory activity against a panel of cancer cells, including RCC4, HeLa, Hep G2, U2OS, U251, DU145, TE-1, BT549, HCT8, and MCF7 cells, with IC50 values of 2.65, 0.45, 7.64, 0.44, 5.43, 0.91, 4.35, 0.16, 0.61, and 3.66 μM[1]. CHNQD-00824 (0-8 μM, 7-13 days) dose-dependently inhibits colony formation in BT549 cells[1]. CHNQD-00824 (0-10 μM, 0-24 h) inhibits cell migration of BT549 cells in a time- and concentration dependent manner[1]. CHNQD-00824 (0-8 μM, 24 h) induces G2 phase cell cycle arrest, and induces apoptosis via DNA damage in a concentration- and caspase-dependent manner in BT549 cells[1].
References:
[1]. Cao XZ, et al. A Terphenyllin Derivative CHNQD-00824 from the Marine Compound Library Induced DNA Damage as a Potential Anticancer Agent. Mar Drugs. 2023 Sep 27;21(10):512.
| Cas No. | 2222643-74-3 | SDF | |
| Formula | C26H26O5 | M.Wt | 418.48 |
| Solubility | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3896 mL | 11.948 mL | 23.896 mL |
| 5 mM | 477.9 μL | 2.3896 mL | 4.7792 mL |
| 10 mM | 239 μL | 1.1948 mL | 2.3896 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)