YUKA1 |
| Catalog No.GC37956 |
YUKA1은 강력한 세포 투과성 라이신 데메틸라제 5A(KDM5A) 억제제로 IC50이 2.66μM이고 KDM5C(IC50, 7.12μM)에서 덜 활성이며 KDM5B, KDM6A 또는 KDM6B에서는 비활성입니다. YUKA1은 항암 활성으로 인간 세포에서 H3K4me3 수준을 증가시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 708991-09-7
Sample solution is provided at 25 µL, 10mM.
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YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1]. IC50: 2.66 μM (KDM5A), 7.12 μM (KDM5C)[1]
[1]. Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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