Histone H3K4Me3 (1-25) amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-26 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription.1 It inhibits several H3K9 methyltransferases and has differential effects on the activities of the KDM7 demethylases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demethylation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer's disease.2
References
1. Pack, L.R., Yamamoto, K.R., and Fujimori, D.G. Opposing chromatin signals direct and regulate the activity of lysine demethylase 4C (KDM4C). J. Biol. Chem. 291(12), 6060-6070 (2016).
2. Mastroeni, D., Delvaux, E., Nolz, J., et al. Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease. Neurobiol. Aging 36(12), 3121-3129 (2015).