GLPBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Research Areas

Products Related to Cell Cycle/Checkpoint(1536)

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    GC49757Bazedoxifene N-oxide
    CAS: 1174289-22-5
    Purity: >90.00%

    An oxidative degradation product of bazedoxifene

  • GC49771 structure
    GC49771rac-Hesperetin-d3
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    An internal standard for the quantification of hesperetin

  • GC49773 structure
    GC49773Albendazole sulfone-d3
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    An internal standard for the quantification of albendazole sulfone

  • GC49781 structure
    GC49781Benomyl
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    Purity: >95.00%

    A carbamate pesticide

  • GC49804 structure
    GC49804Acridine
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    Purity: >98.00%

    An azaarene

  • GC49835 structure
    GC49835Tumulosic Acid
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    Purity: >98.00%

    트리테르페노이드인 투물로식산은 KLK5 프로테아제 활성을 억제합니다(IC50= 14.84 μM).

  • GC49836 structure
    GC49836Benoxaprofen
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    Purity: >98.00%

    베녹사프로펜(LRCL 3794)은 강력하고 오래 지속되는 항염증 및 해열 화합물입니다.

  • GC49855 structure
    GC49855Harmalol (hydrochloride hydrate)
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    Purity: >98.00%

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  • GC49863 structure
    GC49863Cytarabine 5′-monophosphate
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    Purity: >95.00%

    An active metabolite of cytarabine

  • GC49913 structure
    GC49913Davunetide (acetate)
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  • GC49914 structure
    GC49914Pt(II)-NHC Complex 2C
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    An inducer of immunogenic cancer cell death

  • GC49915 structure
    GC49915Hexa-D-Arginine (trifluoroacetate salt)
    Purity: >95.00%

    A furin inhibitor

  • GC50020 structure
    GC50020Dynamin inhibitory peptide, myristoylated
    CAS: 251634-22-7
    Purity: >98.00%

    미리스토일화된 DynaMin 억제 펩타이드는 amphiphysin과 dynamin의 결합을 방해하는 DynaMin 억제제입니다.

  • GC50043 structure
    GC50043SR 3677 dihydrochloride
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    Potent, selective Rho-kinase (ROCK) inhibitor

  • GC50045 structure
    GC50045PD 166285 dihydrochloride
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    Purity: >98.00%

    P-gp의 기질인 PD 166285 dihydrochloride는 각각 24 및 72 nM의 IC50 값을 갖는 WEE1 억제제 및 약한 Myt1 억제제입니다. PD 166285 이염산염은 Chk1에 대해 3.433 μM의 IC50을 나타냅니다.

  • GC50052 structure
    GC50052Laulimalide
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    Purity: >98.00%

    Microtubule stabilzing agent

  • GC50056 structure
    GC50056UA 62784
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    Purity: >98.00%

    Inhibits microtubule polymerization

  • GC50092 structure
    GC50092RKI 1447 dihydrochloride
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    Purity: >98.00%

    RKI 1447 디히드로클로라이드는 ROCK1 및 ROCK2에 대해 각각 14.5 및 6.2nM의 IC50을 갖는 강력하고 선택적인 ROCK 억제제입니다. RKI 1447 이염산염은 결장직장암 세포 성장을 억제하고 세포자멸사를 촉진합니다.

  • GC50110 structure
    GC50110Mps1-IN-1 dihydrochloride
    CAS: 1883548-93-3
    Purity: >98.00%

    Mps1-IN-1 이염산염은 IC50이 367 nM인 강력하고 ATP 경쟁적인 Mps1 키나제 억제제입니다. Mps1-IN-1 이염산염은 Mps1 유사분열 키나제 활성을 억제하고 SAC(스핀들 어셈블리 체크포인트) 기능을 폐지합니다. Mps1-IN-1 이염산염은 암 세포와 '정상' 세포 모두의 생존력을 감소시킵니다.

  • GC50116 structure
    GC50116OXA 06 dihydrochloride
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    Purity: >98.00%

    Potent ROCK inhibitor

  • GC50145 structure
    GC50145CHR 6494 trifluoroacetate
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    Purity: >98.00%

    CHR 6494 트리플루오로아세테이트는 IC50이 2nM인 강력한 하스핀 억제제입니다. CHR 6494 트리플루오로아세테이트는 히스톤 H3T3 인산화를 억제합니다. CHR 6494 트리플루오로아세테이트는 흑색종 및 유방암을 포함한 암세포의 세포자멸사를 유도합니다. CHR 6494 트리플루오로아세테이트는 암 연구에 사용할 수 있습니다.

  • GC50175 structure
    GC50175CGP 74514 dihydrochloride
    Purity: >98.00%

    Potent cdk1 inhibitor

  • GC50214 structure
    GC50214LCB 03-0110 dihydrochloride
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    Purity: >98.00%

    Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

  • GC50314 structure
    GC50314PF 3758309 dihydrochloride
    Purity: >98.00%

    PF 3758309 dihydrochloride는 Kd 값이 2.7nM이고 Ki 값이 18.7nM인 ATP 경쟁성 p21 활성화 키나제 4(PAK4) 억제제이다.