CHR 6494 trifluoroacetate |
| Catalog No.GC50145 |
CHR 6494 트리플루오로아세테이트는 IC50이 2nM인 강력한 하스핀 억제제입니다. CHR 6494 트리플루오로아세테이트는 히스톤 H3T3 인산화를 억제합니다. CHR 6494 트리플루오로아세테이트는 흑색종 및 유방암을 포함한 암세포의 세포자멸사를 유도합니다. CHR 6494 트리플루오로아세테이트는 암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1458630-17-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.
Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID:21804608
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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