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Transferase

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Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.

Products Related to Transferase(21)

  • GC10106 structure
    GC10106OR-486
    CAS: 7659-29-2
    Purity: >98%

    OR-486(OR-486)은 IC50이 12nM인 강력한 카테콜-O-메틸트랜스퍼라제 억제제입니다.

  • GC10265 structure
    GC10265Manumycin A
    CAS: 52665-74-4
    Purity: >98.00%

    마누마이신 A는 항생제입니다.

  • GC10330 structure
    GC10330Lonafarnib
    CAS: 193275-84-2
    Purity: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC10905 structure
    GC10905Amodiaquine dihydrochloride dihydrate
    CAS: 6398-98-7
    Purity: >99.50%

    4-아미노퀴놀린 계열의 항말라리아제인 Amodiaquine dihydrochloride dihydrate(Amodiaquin dihydrochloride dihydrate)는 강력하고 경구 활성인 히스타민 N-메틸트랜스퍼라제 억제제입니다.

  • GC11524 structure
    GC11524Cystamine dihydrochloride
    CAS: 56-17-7
    Purity: >98%

    transglutaminase inhibitor

  • GC11884 structure
    GC11884GPP 78 hydrochloride
    Purity: >98%

    NAMPT inhibitor

  • GC12449 structure
    GC12449SKF 91488 dihydrochloride
    CAS: 68941-21-9
    Purity: >98%

    histamine N-methyltransferase inhibitor

  • GC12912 structure
    GC12912BCATc Inhibitor 2
    CAS: 406191-34-2
    Purity: >99.00%

    BCATc 억제제 2는 신경퇴행성 질환 연구를 위한 선택적 분지쇄 아미노전이효소(BCAT) 억제제입니다.

  • GC12981 structure
    GC12981OU749
    CAS: 519170-13-9
    Purity: >98%

    γ-Glutamyl transferase (GGT) inhibitor

  • GC14308 structure
    GC14308FK866 (APO866)
    CAS: 658084-64-1
    Purity: >99.50%

    FK866 (APO866)는 니코틴아마이드 포스포리보실트랜스퍼라제 (NAMPT)의 강력하고 선택적인 억제제이다 (K i =0.3nM).

  • GC15274 structure
    GC15274PF-04620110
    CAS: 1109276-89-2
    Purity: >98.00%

    PF-04620110은 IC₅₀이 19nM인 경구 활성, 선택적 디아시릴글리세롤 아실트랜스퍼라제-1(DGAT1) 억제제이다.

  • GC15442 structure
    GC15442Tipifarnib (Zarnestra)
    CAS: 192185-72-1
    Purity: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC15614 structure
    GC15614A922500
    CAS: 959122-11-3
    Purity: >98.50%

    A922500은 인간과 쥐 DGAT-1에 대해 각각 9nM과 22nM의 IC50 값을 가진 강력하고 선택적이고 경구 투여가 가능한 디아시글리세롤 아실전이효소 1(DGAT-1) 억제제이다.

  • GC16129 structure
    GC16129LY 78335
    CAS: 39959-66-5
    Purity: >95.00%

    phenylethanolamine-N-methyltransferase (PNMT) inhibitor

  • GC16310 structure
    GC16310FTI 277 HCl
    CAS: 180977-34-8
    Purity: >99.00%

    FTI 277 HCl은 IC 50 값이 0.5nM인 강력하고 선택적인 페르네실트랜스퍼라제（FTase）억제제로 수엽기 전이효소 I（GGTase I）에 대한 선택성이 약 100배 더 높다.

  • GC16612 structure
    GC16612GGsTop
    CAS: 926281-37-0
    Purity: >95.00%

    GGsTop은 γ - 글루탐일 전펩티다제（GGT）의 불가역적 억제제（Ki = 170μM）이다.

  • GC16738 structure
    GC16738Tunicamycin Mixture
    CAS: 11089-65-9
    Purity: >95.00%

    Tunicamycin Mixture은 동종인 핵간류 항생제의 혼합물로, N-당질화를 억제하고 GlcNAc 인산전달효소(GPT)를 차단한다.

  • GC17046 structure
    GC17046Tris DBA
    CAS: 51364-51-3
    Purity: >98%

    N-myristoyltransferase-1 (NMT-1) inhibitor

  • GC17780 structure
    GC17780FTase Inhibitor II
    CAS: 156707-43-6
    Purity: >98.50%

    Ftase inhibitor

  • GC17921 structure
    GC17921Tolcapone
    CAS: 134308-13-7
    Purity: >98%

    A reversible COMT inhibitor

  • GC10170 structure
    GC10170LB42708
    CAS: 226929-39-1
    Purity: >98%

    LB42708은 강력하고 선택적인 경구 활성 파르네실트랜스퍼라제 억제제입니다.