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| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $54.00 | In Stock | 1 | |
| 5mg | $126.00 | In Stock | 1 | |
| 10mg | $207.00 | In Stock | 1 | |
| 25mg | $324.00 | In Stock | 1 | |
| 50mg | $513.00 | In Stock | 1 |
MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells[1].
[1]. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.
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Cell experiment: |
MDA-MB-231 and C2C12 cells are treated with 50μM of SIRT5 inhibitor MC3482 for 24 h. Ammonia levels are measured in the culture medium every other day[1]. |
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References: [1]. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70. |
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