c-Di-GMP sodium salt |
Catalog No.GC50292 |
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes. This product is sold in units of 730μg, equivalent to 1μmol.
Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID:23142775 |Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID:21947006 |Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID:26282097
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