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Brassicasterol Catalog No.GC19530

Brassicasterol is a phytosterol found in canola and rapeseed oils, marine algae, and shellfish

Size Price Stock Qty
1mg
$90.00
In stock
5mg
$425.00
In stock
10mg
$720.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 474-67-9 SDF Download SDF
Synonyms N/A
Chemical Name ergosta-5,22E-dien-3β-ol
Canonical SMILES CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)C3=CC[C@@]21C
Formula C28H46O M.Wt 398.7
Solubility DMF: 2 mg/ml,DMSO: 0.1 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Brassicasterol is a phytosterol found in canola and rapeseed oils, marine algae, and shellfish.[1] It inhibits recombinant sterol Δ24-reductase with a Ki value of 42.7 μM in vitro. Brassicasterol increases accumulation of demosterol, a cholesterol precursor and substrate of sterol Δ24-reductase, and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner. It also inhibits the hemolytic activity of pneumolysin from S. pneumoniae without affecting bacterial growth at concentrations up to 1,000 μg/ml.[2]

Reference:
[1]. Fernández, C., Suárez, Y., Ferruelo, A.J., et al. Inhibition of cholesterol biosynthesis by Δ22-unsaturated phytosterols via competitive inhibition of sterol Δ24-reductase in mammalian cells Biochem. J. 366(Pt 1), 109-119 (2002).
[2]. Li, H., Zhao, X., Deng, X., et al. Insights into structure and activity of natural compound inhibitors of pneumolysin Sci. Rep. 7:42015, (2017).