N-desmethyl Bendamustine (Synonyms: nor-Bendamustine) |
| Catalog No.GC44348 |
N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine.
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Cas No.: 41515-13-3
Sample solution is provided at 25 µL, 10mM.
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N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine . N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).
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