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KEAP1-Nrf2

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The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products Related to KEAP1-Nrf2(56)

  • GC14352 structure
    GC14352TAT 14
    CAS: 1362661-34-4
    Purity: >98.00%

    Nrf2 activator

  • GC16120 structure
    GC16120AI-3
    CAS: 882288-28-0
    Purity: >98%

    Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor

  • GC16590 structure
    GC16590Dimethyl Fumarate
    CAS: 624-49-7
    Purity: >97.00%

    nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator

  • GB10587 structure
    GB10587Gingerenone A
    CAS: 128700-97-0
    Purity: >98.00%

    Gingerenone A is an orally active Nrf2-Gpx4 activator with an EC 50 value of 24μM.

  • GC11302 structure
    GC11302Hinokitiol
    CAS: 499-44-5
    Purity: >98.00%

    Hinokitiol is a naturally occurring tropolone compound from the Formosan cypress with antibacterial and anticancer properties.

  • GC12821 structure
    GC12821Oltipraz
    CAS: 64224-21-1
    Purity: >99.50%

    Oltipraz is an HIF-1α inhibitor (IC 50 =10μM) and an Nrf2 activator.

  • GC13058 structure
    GC13058NK 252
    CAS: 1414963-82-8
    Purity: >98.00%

    NK 252 is an Nrf2 activator.

  • GC13693 structure
    GC13693Omaveloxolone (RTA-408)
    CAS: 1474034-05-3
    Purity: >98.00%

    Omaveloxolone (RTA-408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO).

  • GC15355 structure
    GC153552-Trifluoromethyl-2'-methoxychalcone
    CAS: 1309371-03-6
    Purity: >98.00%

    Nrf2 activator

  • GC15457 structure
    GC15457Pyridoxine
    CAS: 65-23-6
    Purity: >99.50%

    A 4-methanol form of vitamin B 6

  • GC15605 structure
    GC15605Ezetimibe
    CAS: 163222-33-1
    Purity: >99.00%

    Ezetimibe is a selective cholesterol absorption inhibitor with IC 50 values of 50μM for lung cancer cell (A549), human embryonic kidney cells (HEK293) and 30μM for melanoma cell (A375) for 48h.

  • GC17393 structure
    GC17393Pyridoxine HCl
    CAS: 58-56-0
    Purity: >99.50%

    Pyridoxine HCl is the hydrochloride form of vitamin B6 that functions as an antioxidant.

  • GC19254 structure
    GC19254ML385
    CAS: 846557-71-9
    Purity: >98.00%

    ML385 is a cell-active NRF2 inhibitor (IC 50 =1.9μM).

  • GC31321 structure
    GC31321KI696
    CAS: 1799974-70-1
    Purity: >99.00%

    KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.

  • GC31648 structure
    GC316484-Octyl Itaconate
    CAS: 3133-16-2
    Purity: >98.00%

    4-Octyl Itaconate (4-OI) is a cell-permeable itaconate derivative.

  • GC31691 structure
    GC31691(+)-DHMEQ
    CAS: 287194-41-6
    Purity: >99.50%

    (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2.

  • GC31783 structure
    GC31783Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester)
    CAS: 2150-43-8
    Purity: >98.00%

    Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea.

  • GC32723 structure
    GC32723CDDO-Im (RTA-403)
    CAS: 443104-02-7
    Purity: >98.00%

    CDDO-Im (RTA-403) is a synthetic triterpenoid that activates Nuclear factor erythroid 2–related factor 2 (Nrf2) signaling by binding to Kelch-like ECH-associated protein 1 (Keap1), thereby inhibiting Nrf2 degradation and increasing its protein levels.

  • GC33092 structure
    GC33092Hesperin
    CAS: 4430-35-7
    Purity: >98.00%

    An isothiocyanate with diverse biological activities

  • GC33815 structure
    GC338154-Hydroxyphenylacetic acid
    CAS: 156-38-7
    Purity: >99.00%

    A phenolic acid with anti-inflammatory activity

  • GC34057 structure
    GC34057TBHQ (tert-Butylhydroquinone)
    CAS: 1948-33-0
    Purity: >99.50%

    TBHQ(tert-Butylhydroquinone) is a powerful phenolic antioxidant capable of reducing oxidative stress and inflammatory reactions.

  • GC34070 structure
    GC34070Brusatol
    CAS: 14907-98-3
    Purity: >98.00%

    Brusatol is an Nrf2 inhibitor isolated from Brucea javanica and exhibits significant tumor inhibition in multiple cancers through decreased resistance to cancer oxidative stress injury.

  • GC34642 structure
    GC34642KI696 isomer
    CAS: 1799974-69-8
    Purity: >99.00%

    KI696 isomer is the less active isomer of KI696.

  • GC35629 structure
    GC35629CDDO-dhTFEA
    CAS: 1191265-33-4
    Purity: >99.50%

    CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.