Nuclear Receptors

Z-Guggulsterone is a steroidal plant active ingredient derived from Commiphora mukul and can promote cancer cell apoptosis.

GSK 4112 is a selective REV-ERBα agonist, with an EC 50 value of 0.4μM.

inverse agonist of steroidogenic factor 1 (SF-1)

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor

SR9009 is a potent REV-ERBα/β agonist with EC 50 values of 0.67μM and 0.8μM for REV-ERBα and REV-ERBβ, respectively.

HNF4α antagonist

DLPC (DLPC) is an LRH-1 agonist ligand.

inverse agonist of RORγ, potent and selective

RORα and γ inverse agonist

SR 8278 is an antagonist of the nuclear receptor REV-ERBα that can inhibit the transcription of REV-ERBα with an EC 50 value of 0.47μM.

REV-ERB-α/β agonist

DAF-12 activator

Guggulsterone is a plant sterol extracted from the resin of the plant Commiphora wightii. Guggulsterone can inhibit the growth of a wide variety of tumor cells and induce apoptosis through downregulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), modulation of cell cycle proteins (such as Cyclin D1 and c-Myc), activation of caspases, inhibition of Akt, and activation of JNK.