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DLPC (Synonyms: 1,2Dilauroylsnglycero3Phosphocholine, 1,2-DLPC)

Catalog No.GC14047

DLPC (DLPC) is an LRH-1 agonist ligand.

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DLPC Chemical Structure

Cas No.: 18194-25-7

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10mM (in 1mL EtOH)
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50mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IC50: N/A

DLPC is an LRH-1 agonist ligand.

The orphan nuclear receptor liver receptor homolog-1 (LRH-1) is recognized as a critical regulator of bile salt biosynthesis. Bile salts are recognized increasingly as modulators of glucose and lipid metabolism in both human and animals.

In vitro: In a cell-free system, DLPC specifically bound to a recombinant LRH-1 ligand-binding domain. At functional level, DLPC was found to be a strong activator of both human and mouse LRH-1, while other nuclear receptors including FXR, CAR, PXR, PPARa and PPARc were all unaffected by DLPC in cell culture. In addition, DLPC induced the transactivation of the native mouse Shp and Oct4 promoters, consistent with previous studies on Lrh-1. In HepG2 cell line, DLPC could induce the expression of CYP8B1 [1].

In vivo: In mouse in vivo test, DLPC induced bile acid biosynthetic enzymes in mouse liver, lowered hepatic triglycerides and serum glucose, and increased bile acid levels. Moreover, DLPC treatment was also able to decrease hepatic steatosis and improve glucose homeostasis in two mouse models of insulin resistance [1].

Clinical trial: In a previous clinical study, single-dose inhalations of liposome preparations of Bec-DLPC and DLPC alone were administered. Results showed that no adverse clinical or laboratory events were observed. Thus, it was concluded that DLPC liposome aerosol was well tolerated in doses equivalent to those administered by MDIs for treatment of asthma [2].

References:
[1] Hohenester S,Beuers U.  Phosphatidylcholines as regulators of glucose and lipid homeostasis: promises and potential risks. Hepatology.2011 Dec;54(6):2265-7.
[2] Waldrep JC,Gilbert BE,Knight CM,Black MB,Scherer PW,Knight V,Eschenbacher W. Pulmonary delivery of beclomethasone liposome aerosol in volunteers. Tolerance and safety. Chest.1997 Feb;111(2):316-23.

Chemical Properties

Cas No. 18194-25-7 SDF
Synonyms 1,2Dilauroylsnglycero3Phosphocholine, 1,2-DLPC
Chemical Name (R)-2,3-bis(dodecanoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
Canonical SMILES O=C(CCCCCCCCCCC)O[C@@H](CO[P@](OCC[N+](C)(C)C)([O-])=O)COC(CCCCCCCCCCC)=O
Formula C32H64NO8P M.Wt 621.83
Solubility 100 mg/mL in Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.6082 mL 8.0408 mL 16.0816 mL
5 mM 0.3216 mL 1.6082 mL 3.2163 mL
10 mM 0.1608 mL 0.8041 mL 1.6082 mL
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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