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Home >> Signaling Pathways >> Angiogenesis >> HIF

HIF

Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.

Products for  HIF

  1. Cat.No. Product Name Information
  2. GC16195 2,4-DPD

    2,4-Diethylpyridine dicarboxylate

     Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. 2,4-DPD Chemical Structure
  3. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     3-acetyl-11-keto-β-Boswellic Acid (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. 3-acetyl-11-keto-β-Boswellic Acid Chemical Structure
  4. GC35230 Acetylarenobufagin Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-I) modulator. Acetylarenobufagin Chemical Structure
  5. GC32083 Acriflavine Acriflavine is a fluorescent dye for labeling high molecular weight RNA. Acriflavine Chemical Structure
  6. GC12487 Adaptaquin

    HIF prolyl hydroxylase inhibitor

     HIF-prolyl hydroxylase-2 (PHD2) inhibitor Adaptaquin Chemical Structure
  7. GC33416 AFP464

    NSC710464 free base

     AFP464 (NSC710464 free base), is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator. AFP464 Chemical Structure
  8. GC12698 BAY 87-2243 A HIF-1 inhibitor,potent and selective BAY 87-2243 Chemical Structure
  9. GC16647 Daprodustat(GSK1278863)

    GSK1278863

     Daprodustat(GSK1278863) (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease. Daprodustat(GSK1278863) Chemical Structure
  10. GC31230 Dencichin (Dencichine) Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity. Dencichin (Dencichine) Chemical Structure
  11. GC38767 Deoxyshikonin A natural products with anti-tumor activity Deoxyshikonin Chemical Structure
  12. GC32449 Desidustat

    P 1560, β-Zearalanol, β-Zearanol

     An inhibitor of HIF-PH Desidustat Chemical Structure
  13. GC18236 Echinomycin

    Antibiotic A 654I； NSC 13502； NSC 526417； Quinomycin A； SK 302B

     An inhibitor of HIF1mediated gene transcription Echinomycin Chemical Structure
  14. GC33043 EL-102 EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer. EL-102 Chemical Structure
  15. GC33634 Enarodustat (JTZ-951)

    JTZ-951

     Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat (JTZ-951) Chemical Structure
  16. GC33170 ENMD-119 (ENMD 1198)

    IRC-110160

     ENMD-119 (ENMD 1198) (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-119 (ENMD 1198) is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization. ENMD-119 (ENMD 1198) Chemical Structure
  17. GC16638 FG2216

    IOX3, YM-311

     HIF-prolyl hydroxylase inhibitor FG2216 Chemical Structure
  18. GC38044 Fraxinellone Fraxinellone Chemical Structure
  19. GC30263 Glucosamine (D-Glucosamine) Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine (D-Glucosamine) Chemical Structure
  20. GC34595 GN44028 A HIF-1 inhibitor GN44028 Chemical Structure
  21. GC39146 HIF-1 inhibitor-1 An inhibitor of HIF-1 signaling HIF-1 inhibitor-1 Chemical Structure
  22. GC31358 HIF-2α-IN-1 HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. HIF-2α-IN-1 Chemical Structure
  23. GC11767 Hydralazine HCl

    1-Hydrazinophthalazine

     Hydralazine HCl is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel. Hydralazine HCl Chemical Structure
  24. GC32948 IDF-11774 A novel HIF-1 inhibitor IDF-11774 Chemical Structure
  25. GC12255 IOX4 PHD2 inhibitor IOX4 Chemical Structure
  26. GC15379 JNJ-42041935

    HIF-PHD Inhibitor II

     Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor JNJ-42041935 Chemical Structure
  27. GC32724 LW6 (HIF-1α inhibitor)

    Hypoxia-Inducible Factor1α Inhibitor

     LW6 is a hypoxia-inducing factor 1(HIF) inhibitor, which effectively inhibits HIF-1α accumulation by degrading HIF-1α, but does not affect HIF-1A mRNA level during hypoxia. LW6 (HIF-1α inhibitor) Chemical Structure
  28. GC19251 MK-8617 MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. MK-8617 Chemical Structure
  29. GC10046 Molidustat (BAY85-3934)

    Molidustat

     Molidustat (BAY85-3934) (BAY 85-3934) is a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with mean IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM for PHD3. Molidustat (BAY85-3934) Chemical Structure
  30. GC17358 Octyl-α-ketoglutarate

    α-KG octyl ester

     prolyl hydroxylases (PHD) activator Octyl-α-ketoglutarate Chemical Structure
  31. GC12821 Oltipraz

    NSC 347901, RP 35972

     Nrf2 activator;An antischistosomal agent Oltipraz Chemical Structure
  32. GC41625 Oroxylin A

    6-Methoxybaicalein

    Oroxylin A is a flavonoid that has been found in S.

     Oroxylin A Chemical Structure
  33. GC32680 PT-2385 PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. PT-2385 Chemical Structure
  34. GC37034 PT2977

    PT2977; MK-6482

     PT2977 (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 Chemical Structure
  35. GC11031 PX-478 2HCl

    PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.

     PX-478 2HCl Chemical Structure
  36. GC37066 Rac-PT2399 A potent and specific HIF-2α inhibitor Rac-PT2399 Chemical Structure
  37. GC32876 SYP-5 A HIF-1 inhibitor SYP-5 Chemical Structure
  38. GC32945 THS-044 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. THS-044 Chemical Structure
  39. GC32228 Tilorone dihydrochloride

    NSC 143969

     An interferon-inducing antiviral agent Tilorone dihydrochloride Chemical Structure
  40. GC37801 TM6089 TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. TM6089 Chemical Structure
  41. GC31498 TP0463518

    TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor

     TP0463518 Chemical Structure
  42. GC16811 Vadadustat

    AKB6548, PG-1016548

     HIF-PH inhibitor Vadadustat Chemical Structure
  43. GC37889 VCE-004.8

    VCE-?004.8

     VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist. VCE-004.8 Chemical Structure
  44. GC37966 ZINC13466751 ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M. ZINC13466751 Chemical Structure

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