Home >> Signaling Pathways >> Angiogenesis >> HIF

HIF

Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.

  1. Cat.No. Product Name Information
  2. GC16195 2,4-DPD cell permeable, competitive inhibitor of HIF-PH
  3. GC15084 2-Methoxyestradiol (2-MeOE2)

    Apoptotic, antiproliferative and antiangiogenic agent

  4. GC14282 3-acetyl-11-keto-β-Boswellic Acid 5-lipoxygenase inhibitor
  5. GC32083 Acriflavine
  6. GC12487 Adaptaquin HIF-prolyl hydroxylase-2 (PHD2) inhibitor
  7. GC33416 AFP464
  8. GC12698 BAY 87-2243 HIF-1 inhibitor,potent and selective
  9. GN10518 Chitosamine hydrochloride Extracted from natural chitin;Store the product in sealed, cool and dry condition
  10. GN10308 Chlorogenic acid Extracted from Lonicera acuminata.Wall.;Suitability:Ethanol and acetone;Store the product in sealed,cool and dry condition
  11. GC16647 Daprodustat(GSK1278863) HIF-prolyl hydroxylase inhibitor
  12. GC31230 Dencichin (Dencichine)
  13. GC38767 Deoxyshikonin
  14. GC32449 Desidustat
  15. GC16973 DMOG Competitive HIF-PH inhibitor, cell-permeable
  16. GC18236 Echinomycin Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion.
  17. GC33043 EL-102
  18. GC33634 Enarodustat (JTZ-951)
  19. GC33170 ENMD-119 (ENMD 1198)
  20. GC13139 FG-4592 (ASP1517) HIF prolyl-hydroxylase inhibitor
  21. GC16638 FG2216 HIF-prolyl hydroxylase inhibitor

Items 1 to 20 of 50 total

per page
  1. 1
  2. 2
  3. 3

Set Descending Direction