GLPBio

Dopamine Receptor

Dopamine receptors (DR) are members of G protein-coupled receptors superfamily. There are 5 subtypes (D1, D2, D3, D4, D5) of DR which mediate the functions of dopamine in central nervous system for control of locomotion, cognition, and emotion etc.

Products Related to Dopamine Receptor(300)

  • GC68307 structure
    GC68307Fluphenazine-d8 dihydrochloride
    Purity: >98%
  • GC68383 structure
    GC68383(R)-Preclamol
    CAS: 85976-54-1
    Purity: >98%
  • GC68420 structure
    GC68420Propionylpromazine-d6 hydrochloride
    CAS: 1262770-67-1
    Purity: >98%
  • GC68997 structure
    GC68997Dopamine-d5 hydrochloride
    CAS: 2193106-55-5
    Purity: >98%

    Dopamine-d5 (hydrochloride) is a deuterium-labeled form of Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter produced in the substantia nigra, ventral tegmental area, and hypothalamus that plays an important role in the brain and body. Dopamine hydrochloride (ASL279) induces internalization of VEGFR2 through D2 dopamine receptor activation, which is crucial for promoting angiogenesis.

  • GC69463 structure
    GC69463(-)-GSK598809 hydrochloride
    CAS: 863766-31-8
    Purity: >99.00%

    (-)-GSK598809 is an isomer of GSK598809. GSK598809 is a selective antagonist of the dopamine D3 receptor (DRD3).

  • GC69634 structure
    GC69634OS-3-106
    CAS: 1580000-17-4
    Purity: >96.00%

    OS-3-106 is an effective and selective dopamine D3 receptor (D3R) agonist that can penetrate the blood-brain barrier. It has a high affinity for D3R (Ki = 0.2 nM). OS-3-106 can be used in research on stimulant addiction.

  • GC69909 structure
    GC69909SKF 83822
    CAS: 74115-08-5
    Purity: >98.00%

    SKF 83822 is an atypical dopamine D1 receptor agonist. It activates adenylate cyclase (AC) but not phospholipase C (PLC). SKF 83822 has also been shown to stimulate AC through the production of cAMP. It can be used in research on schizophrenia.

  • GC69910 structure
    GC69910SKF 83959
    CAS: 80751-85-5
    Purity: >98%

    SKF83959 is an effective selective partial agonist of dopamine D1-like receptors. The Ki values for rat D1, D5, D2 and D3 are 1.18, 7.56, 920 and 399 nM respectively. SKF83959 is also an effective sigma (σ)-1 receptor allosteric modulator. It belongs to the benzazepine family and has been shown to improve cognitive dysfunction. SKF83959 can be used in research on Alzheimer's disease and depression.

  • GC70086 structure
    GC70086UCM-1306
    CAS: 2258608-78-3
    Purity: >99.00%

    UCM-1306 is an orally effective positive allosteric modulator (PAM) of the human dopamine D1 receptor. UCM-1306 increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors. It not only improves motor symptoms but also addresses key comorbid cognitive impairments associated with long-term Parkinson's disease (PD).

  • GC70092 structure
    GC70092UNC9995
    CAS: 1354030-52-6
    Purity: >99.00%

    UNC9995 is an agonist of the dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thereby preventing neuronal degeneration. In addition, UNC9995 activates Drd2/β-arrestin2 signaling to block inflammation-related gene transcription induced by JAK/STAT3. UNC9995 also improves depressive behavior in mouse models and ameliorates astrocyte dysfunction.

  • GC70176 structure
    GC70176Zuclopenthixol dihydrochloride
    CAS: 58045-23-1
    Purity: >99.00%

    Zuclopenthixol dihydrochloride is a thioxanthene derivative and an antagonist of dopamine D1/D2 receptors. It can be used for research on schizophrenia.

  • GC70530 structure
    GC70530SKF 81297
    CAS: 71636-61-8
    Purity: >98.00%

    SKF 81297 is a potent and selective dopamine D1 receptor agonist.

  • GC70554 structure
    GC70554MLS1082
    CAS: 883958-36-9
    Purity: >99.00%

    MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling.

  • GC70734 structure
    GC70734Fallypride
    CAS: 166173-78-0

    Fallypride is a potent antagonist of dopamine D2/D3 receptor.

  • GC70745 structure
    GC70745Blonanserin-d5
    CAS: 1346599-86-7

    Blonanserin-d5 is a deuterium labeled Blonanserin.

  • GC70921 structure
    GC70921Haloperidol-d4-1
    CAS: 136765-35-0
    Purity: >98.00%

    Haloperidol-d4-1 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

  • GC71157 structure
    GC71157Dopamine D2 receptor agonist-2
    CAS: 1610591-93-9

    Dopamine D2 receptor agonist-2 (compound 36) is a potent dopamine D2 receptor biased agonism ligand with an Ki value of 11.2 nM.

  • GC71511 structure
    GC71511Dexpramipexole-d3 dihydrochloride
    CAS: 1432230-09-5

    Dexpramipexole-d3 (dihydrochloride) is the deuterium labeled Dexpramipexole.

  • GC71653 structure
    GC71653Domperidone monomaleate
    CAS: 83898-65-1
    Purity: >99.00%

    Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist.

  • GC71717 structure
    GC71717Cinitapride
    CAS: 66564-14-5
    Purity: >98.00%

    Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist.

  • GC73801 structure
    GC73801Fallypride precursor
    CAS: 166173-74-6
    Purity: >98.00%

    Fallypride precursor (Compound 15) can be used for synthesis of Fallypride.

  • GC74238 structure
    GC74238L-DOPA-13C
    CAS: 586971-29-1
    Purity: >99.50%

    L-DOPA-13C is the 13C labeled L-DOPA.

  • GC79284 structure
    GC79284(S)-SCH-23390 hydrochloride
    CAS: 1217443-99-6
    Purity: >99.00%

    (S)-SCH-23390 hydrochloride is the S-enantiomer of SCH-23390.

  • GC79285 structure
    GC79285Cariprazine impurity 1
    CAS: 791778-53-5
    Purity: >98.00%

    Cariprazine impurity 1 is a dopamine D2 receptor ( D2R ) agonist.