Dopamine Receptor

Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine.

(Rac)-PF-06256142 is the less effective enantiomer of PF-06256142.

Desmethyl cariprazine is an active metabolite of Cariprazine.

Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain.

FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeking behavior.

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptorpositive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM).

PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP).

Trifluoperazine (TFP) is an antagonist against dopamine receptors, act as antipsychotic agent and is widely used to treat schizophrenia or related psychoses.

Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties.

Medifoxamine is a monoamine re-uptake inhibiting antidepressive drug which preferentially inhibits dopamine reuptake.

Aramisulpride is a dopamine D2 receptor and serotonin receptor antagonist used for the research of metabolic disorders.

(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist.

Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator.

Spiperone is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist.

Bromperidol (R-11333) hydrochloride possesses antipsychotic activity, with a high affinity for central dopamine receptors D2.

Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist.

Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist.

UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling.

PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC50 and Ki of 33 nM and 12 nM, respectively.

N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research.