Estrogen/progestogen Receptor

A substrate of multidrug resistance protein 2

An internal standard for the quantification of desogestrel

A metabolite of estrone

A metabolite of dehydroepiandrosterone

An active metabolite of estrone

An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen

A metabolite of 17β-estradiol

A progesterone receptor agonist and metabolite of progesterone

An active metabolite of spironolactone

(S)-Equol is an isoflavone compound produced by the gut microbiota of some individuals, primarily derived from the metabolism of daidzein in soybeans by specific gut bacteria. (S)-Equol exhibits significant estrogenic activity and antioxidant properties, binding to estrogen receptors with an affinity for ERβ of Ki=0.73±0.2nM and for ERα of Ki=6.41±1nM.

An active metabolite of estrone

Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor.

A synthetic steroid and inhibitor of estrogen 2-hydroxylase

An oxidative degradation product of bazedoxifene

An active metabolite of estrone

An estrogen receptor antagonist and a derivative of fulvestrant

Potent and selective ERβ agonist; neuroprotective

WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity.

Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

An alkylphenolethoxylate and a degradation product of non-ionic surfactants

An internal standard for the quantification of drospirenone

SAR439859 (compound 43d) is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD). SAR439859 is a potent ER antagonist and has ER degrading activity with an EC50 of 0.2 nM for ERα degradation. SAR439859 demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer.

Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA).

Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity.