AC 186 |
| Catalog No.GC50091 |
Potent and selective ERβ agonist; neuroprotective
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1421854-16-1
Sample solution is provided at 25 µL, 10mM.
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Potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.
George et al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537 PMID:24020966 |McFarland et al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249 PMID:23898966
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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