GLPBio

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products Related to TRP Channel(184)

  • GC14065 structure
    GC14065Capsaicin
    CAS: 404-86-4
    Purity: >99.50%

    Capsaicin is a highly selective agonist for the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), a ligand-gated, nonselective cation channel, preferentially expressed on small-diameter sensory neurons.

  • GC14248 structure
    GC14248SB 452533
    CAS: 459429-39-1
    Purity: >98.00%

    TRPV1 antagonist

  • GC14276 structure
    GC14276BCTC
    CAS: 393514-24-4
    Purity: >99.00%

    vanilloid receptor 1 (TRPV1 receptor) antagonist

  • GC14387 structure
    GC14387WS 3
    CAS: 1421227-52-2
    Purity: >98.00%

    TRPM8 receptor agonist

  • GC14537 structure
    GC14537AMTB hydrochloride
    CAS: 926023-82-7
    Purity: >98%

    TRPM8 channel blocker

  • GC14580 structure
    GC14580SB705498
    CAS: 501951-42-4
    Purity: >99.50%

    SB705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated of TRPV1 receptors (pKis = 7.6; 7.5; and 7.3 for human, rat, and guinea pig, respectively).SB705498 rapidly and reversibly inhibits capsaicin-, acid-, or heat-mediated activation of human TRPV1.

  • GC14635 structure
    GC14635RQ-00203078
    CAS: 1254205-52-1
    Purity: >99.00%

    Selective and orally active TRPM8 antagonist

  • GC14641 structure
    GC14641SKF 96365 hydrochloride
    CAS: 130495-35-1
    Purity: >98.00%

    SKF 96365 hydrochloride is an orally active TRP-channel/store-operated Ca²⁺ entry (SOCE) inhibitor that blocks TRPC channels, voltage-gated Ca²⁺ channels and multiple K⁺ channels, and suppresses STIM1-mediated Ca²⁺ signaling.

  • GC14649 structure
    GC14649Pyr3
    CAS: 1160514-60-2
    Purity: >99.50%

    Pyr3 is a potent and selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC 50 of 700nM for TRPC3-mediated Ca 2+ influx.

  • GC14761 structure
    GC14761Mavatrep
    CAS: 956274-94-5
    Purity: >99.50%

    TRPV1 antagonist

  • GC14997 structure
    GC14997SB 366791
    CAS: 472981-92-3
    Purity: >98.00%

    SB 366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist with an IC 50 value of 5.7nM.

  • GC15208 structure
    GC15208TC-I 2000
    CAS: 1159996-20-9
    Purity: >98%

    TRPM8 channel blocker

  • GC15346 structure
    GC15346RN 1747
    CAS: 1024448-59-6
    Purity: >99.50%

    TRPV4 agonist

  • GC15417 structure
    GC15417STEARDA
    CAS: 105955-10-0
    Purity: >98%

    potentiates TRPV1-mediated effects of NADA

  • GC15427 structure
    GC15427JNJ 17203212
    CAS: 821768-06-3
    Purity: >99.00%

    TRPV1 antagonist

  • GC15893 structure
    GC15893EIPA
    CAS: 1154-25-2
    Purity: >98.00%

    EIPA inhibited TRPP3-mediated Ca2+-activated currents with IC50 values of 10.5 µM.

  • GC16444 structure
    GC16444Rosiglitazone
    CAS: 122320-73-4
    Purity: >98.00%

    Rosiglitazone is an orally active peroxisome proliferator-activated receptor gamma (PPARγ) selective agonist that selectively activates chimeras containing the PPARγ ligand-binding domain (LBD) but not PPARα and PPARδ with an EC 50 of 60 nM and a K d of 40nM.

  • GC16467 structure
    GC16467Olvanil
    CAS: 58493-49-5
    Purity: >98.00%

    vanilloid receptor agonist

  • GC16700 structure
    GC16700PALDA
    CAS: 136181-87-8
    Purity: >98%

    PALDA (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1.

  • GC16760 structure
    GC16760WS 12
    CAS: 68489-09-8
    Purity: >99.50%

    TRPM8 agonist

  • GC16801 structure
    GC168015'-Iodoresiniferatoxin
    CAS: 535974-91-5
    Purity: >98%

    TRPV1 (VR1) receptor antagonist

  • GC16825 structure
    GC16825Probenecid
    CAS: 57-66-9
    Purity: >98.00%

    inhibitor of organic anion transport, MRP and pannexin-1 channel

  • GC16850 structure
    GC16850ML SA1
    CAS: 332382-54-4
    Purity: >98.00%

    ML SA1 is a selective TRPML agonist with an EC 50 value of 15.3μM.

  • GC16917 structure
    GC16917GSK 2193874
    CAS: 1336960-13-4
    Purity: >98.00%

    TRPV4 antagonist, potent and selective