GLPBio

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products Related to TRP Channel(184)

  • GC33158 structure
    GC33158D-3263
    CAS: 947257-66-1
    Purity: >98%

    D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

  • GC33423 structure
    GC33423JT010
    CAS: 917562-33-5
    Purity: >98.00%

    A TRPA1 channel agonist

  • GC33424 structure
    GC33424SAR7334
    CAS: 1333210-07-3
    Purity: >99.50%

    SAR7334 is a highly potent and specific TRPC6 channel inhibitor (IC₅₀=7.9nM). SAR7334 also inhibits TRPC3- and TRPC7-mediated Ca²⁺ influx into cells.

  • GC33443 structure
    GC33443Pyr6
    CAS: 245747-08-4
    Purity: >99.00%

    Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).

  • GC33675 structure
    GC33675Podocarpic acid
    CAS: 5947-49-9
    Purity: >98.00%

    Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

  • GC34489 structure
    GC34489BI-749327
    CAS: 2361241-23-6
    Purity: >98.00%

    BI-749327 is a highly selective transient receptor potential canonical 6 (TRPC6) channel antagonist that potently inhibits TRPC6 activity in mice, humans, and guinea pigs (IC 50 =13nM, 19nM, and 15nM).

  • GC34833 structure
    GC34833TC-I 2014
    CAS: 1221349-53-6
    Purity: >99.00%

    TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively.

  • GC34951 structure
    GC34951(-)-Menthol
    CAS: 2216-51-5
    Purity: >98.00%

    A monoterpene with diverse biological activities

  • GC35010 structure
    GC35010(Z)-Capsaicin
    CAS: 25775-90-0
    Purity: >99.50%

    (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.

  • GC35222 structure
    GC35222ABT-239
    CAS: 460746-46-7
    Purity: >99.00%

    ABT-239 is a novel, highly efficacious, non-imidazole?class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

  • GC35316 structure
    GC35316AMG2850
    CAS: 1470018-52-0
    Purity: >98%

    AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist.

  • GC35407 structure
    GC35407Asivatrep
    CAS: 1005168-10-4
    Purity: >95.00%

    Asivatrep is a potent, selective, and nonsteroidal antagonist transient receptor potential vanilloid subfamily V member 1 (TRPV1).

  • GC35501 structure
    GC35501Beta-Eudesmol
    CAS: 473-15-4
    Purity: >98.00%

    A sesquiterpene with diverse biological activities

  • GC35970 structure
    GC35970EIPA hydrochloride
    CAS: 1345839-28-2
    Purity: >98.00%

    EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM.

  • GC36277 structure
    GC36277Hydroxy-α-sanshool
    CAS: 83883-10-7
    Purity: >98.00%

    Hydroxy-α-sanshool is a transient receptor potential base 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC 50 values of 69 and 1.1μM, respectively, commonly used in hyperlipidemia studies.

  • GC36609 structure
    GC36609Mifamurtide
    CAS: 83461-56-7
    Purity: >95.00%

    Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes.

  • GC36627 structure
    GC36627ML204 hydrochloride
    CAS: 2070015-10-8
    Purity: >99.50%

    ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.

  • GC37655 structure
    GC37655SN 2
    CAS: 823218-99-1
    Purity: >99.50%

    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM.

  • GC37831 structure
    GC37831TRPM8 agonist WS-3
    CAS: 39711-79-0
    Purity: >99.00%

    TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM.

  • GC38501 structure
    GC38501GSK205
    CAS: 1263068-83-2
    Purity: >97.00%

    GSK205 is a highly selective antagonist of the TRPV4 ion channel (IC 50 = 4.19μM).

  • GC38726 structure
    GC387261,4-Cineole
    CAS: 470-67-7
    Purity: >98.00%

    1,4-Cineole is a widely distributed, natural, oxygenated monoterpene.

  • GC39117 structure
    GC39117Methyl syringate
    CAS: 884-35-5
    Purity: >99.50%

    Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases.

  • GC39198 structure
    GC39198GSK1702934A
    CAS: 924377-85-5
    Purity: >98.00%

    A TRPC3 and TRPC6 activator

  • GC39387 structure
    GC39387GSK2798745
    CAS: 1419609-94-1
    Purity: >98.00%

    GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel with IC 50 of 1.8 and 1.6nM for hTRPV4 and rTRPV4, respectively.