TRP Channel
TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.
Products for TRP Channel
- Cat.No. Product Name Information
- GC33675 Podocarpic acid Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.
- GC12580 Polygodial TRPA1 channel activator
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GC11293
PPAHV
vanilloid TRPV1 (VR1) receptor agonist
- GC65106 Pregnenolone-d4-1
- GC16825 Probenecid inhibitor of organic anion transport, MRP and pannexin-1 channel
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GC30096
Pyr10
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor.
- GC14649 Pyr3 canonical transient receptor potential channel 3 (TRPC3) antagonist
- GC33443 Pyr6 Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
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GC12783
Resiniferatoxin
Resiniferatoxin is a selective TRPV1 receptor agonist that activates TRPV1 in an irreversible manner.
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GC44816
Resolvin D2
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.
- GC17267 RN 1734 TRPV4 antagonist
- GC15346 RN 1747 TRPV4 agonist
- GC45907 RN-9893 (hydrochloride) A TRPV4 antagonist
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GC16444
Rosiglitazone
A PPARγ agonist
- GC11318 Rosiglitazone maleate A PPARγ agonist
- GC14635 RQ-00203078 Selective and orally active TRPM8 antagonist
- GC33424 SAR7334 SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
- GC14997 SB 366791 vanilloid TRPV1 receptor antagonist
- GC14248 SB 452533 TRPV1 antagonist
- GC14580 SB705498 TRPV1 antagonist,potent and selective
- GC50667 SET 2
- GC14641 SKF 96365 hydrochloride Store-operated Ca2+ entry (SOCE) inhibitor
- GC37655 SN 2 SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM.
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GC69928
SOR-C13 TFA
SOR-C13 TFA is a carboxy-terminal truncated peptide and a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage-gated calcium channel that is associated with malignant tumors and poor prognosis in breast cancer. SOR-C13 TFA has anti-cancer activity.
- GC15417 STEARDA potentiates TRPV1-mediated effects of NADA
- GC15208 TC-I 2000 TRPM8 channel blocker
- GC34833 TC-I 2014 TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively.
- GC11185 TCS 5861528 TCS 5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively.
- GC64852 Tivanisiran Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease.
- GC13218 TRPC6 inhibitor TRPC6 inhibitor is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
- GC30546 TRPC6-IN-1 TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM.
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GC70066
TRPC6-IN-3
TRPC6-IN-3 (compound 17) is an orally effective inhibitor of transient receptor potential cation channel subfamily C member 6 (TRPC6). TRPC6-IN-3 can not only regulate intracellular calcium concentration, but also modulate membrane potential by regulating cation flux including calcium and sodium ions. TRPC6-IN-3 can be used for research in the respiratory system.
- GC50590 TRPC6-PAM-C20 Selective TRPC6 positive allosteric modulator
- GC68002 TRPM4-IN-2
- GC37831 TRPM8 agonist WS-3 TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM.
- GC30893 TRPM8 Antagonist TRPM8 Antagonist is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
- GC64086 TRPM8 antagonist 3 TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM.
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GC30725
TRPV antagonist 1
TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC50 of < 250 nM.
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GC70067
TRPV1 antagonist 3
TRPV1 antagonist 3 (Compound 7q) is an effective TRPV1 antagonist with an IC50 value of 2.66 nM against capsaicin. It has mode selectivity and good oral bioavailability (F = 60%), and can penetrate the blood-brain barrier.
- GC65536 TRPV4 agonist-1 TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay.
- GC63244 TRPV4 agonist-1 free base TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay.
- GC65211 Umbellulone Umbellulone is an active constituent of the leaves of Umbellularia californica.
- GC63249 Vanilloid receptor antagonist 1 Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist extracted from patent US8349852B2, compound B8.
- GC16760 WS 12 TRPM8 agonist
- GC14387 WS 3 TRPM8 receptor agonist