GLPBio

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products Related to TRP Channel(184)

  • GC17091 structure
    GC17091A 784168
    CAS: 824982-41-4
    Purity: >98%

    TRPV1 antagonist,potent and selective

  • GC17267 structure
    GC17267RN 1734
    CAS: 946387-07-1
    Purity: >98.00%

    TRPV4 antagonist

  • GC17562 structure
    GC175622-APB
    CAS: 524-95-8
    Purity: >98.00%

    2-APB is a nonspecific antagonist of calcium channels, commonly used in studies of calcium signaling, such as in apoptosis, muscle contraction, and neural transmission.

  • GC17879 structure
    GC17879OLDA
    CAS: 105955-11-1
    Purity: >98.00%

    OLDA (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous TRPV1 selective agonist.

  • GC17918 structure
    GC17918Capsazepine
    CAS: 138977-28-3
    Purity: >99.00%

    Capsazepine is a specific antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor with an IC 50 value of 562nM.

  • GC17940 structure
    GC17940GSK1016790A
    CAS: 942206-85-1
    Purity: >98.00%

    GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist.

  • GC18020 structure
    GC18020AP 18
    CAS: 55224-94-7
    Purity: >99.50%

    AP 18 is a potent and selective TRPA1 inhibitor, blocking activation of TRPA1 by 50μM Cinnamaldehyde with an IC 50 value of 4.5μM for mouse TRPA1.

  • GC18069 structure
    GC18069Cardamonin
    CAS: 19309-14-9
    Purity: >98.00%

    Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.

  • GC18296 structure
    GC18296M8-B (hydrochloride)
    CAS: 883976-12-3
    Purity: >98.00%

    M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively).

  • GC18564 structure
    GC18564MK6-83
    CAS: 1062271-24-2
    Purity: >99.00%

    MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1).

  • GC19025 structure
    GC19025AM-0902
    CAS: 1883711-97-4
    Purity: >99.50%

    AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.

  • GC19291 structure
    GC19291PF-4840154
    CAS: 1332708-14-1
    Purity: >99.50%

    PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively.

  • GC19729 structure
    GC19729Adenosine 5′-diphosphoribose sodium
    CAS: 68414-18-6
    Purity: >99.00%

    Adenosine 5′-diphosphoribose sodium is a nucleotide derivative and an agonist of Transient receptor potential melastatin 2 (TRPM2), playing an important role in various metabolic pathways within cells.

  • GC19764 structure
    GC19764ML-SI1
    Purity: >99.50%

    ML-SI1 is a racemic mixture and an inhibitor of transient receptor potential cation channel (TRPML), with an IC 50 value of 15μM for TRPML1.

  • GC30096 structure
    GC30096Pyr10
    CAS: 1315323-00-2
    Purity: >98%

    Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor.

  • GC30546 structure
    GC30546TRPC6-IN-1
    CAS: 901715-05-7
    Purity: >99.50%

    TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM.

  • GC30725 structure
    GC30725TRPV antagonist 1
    CAS: 1192871-27-4
    Purity: >98%

    TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC50 of < 250 nM.

  • GC30799 structure
    GC30799HC-070
    CAS: 1628291-95-1
    Purity: >98.50%

    HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.

  • GC30837 structure
    GC30837A-1165442
    CAS: 1221443-94-2
    Purity: >99.50%

    A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1.

  • GC30893 structure
    GC30893TRPM8 Antagonist
    CAS: 259674-19-6
    Purity: >98.00%

    TRPM8 Antagonist is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.

  • GC31236 structure
    GC31236JYL 1421 (SC 0030)
    CAS: 401907-26-4
    Purity: >98%

    JYL 1421 (SC 0030) is a TRPV1 receptor antagonist, with an IC50 of 8 nM.

  • GC31953 structure
    GC31953Camphor ((±)-Camphor)
    CAS: 76-22-2
    Purity: >98.00%

    Camphor ((±)-Camphor) ((±)-Camphor ((±)-Camphor)) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative.

  • GC32849 structure
    GC32849Pico145 (HC-608)
    CAS: 1628287-16-0
    Purity: >98.50%

    Pico145 (HC-608) is a TRPC1/4/5 channel inhibitor, which can inhibit the TRPC4/TRPC5 channels activated by (-)-englerin A with the IC 50 values of 0.349 and 1.3nM, respectively.

  • GC32961 structure
    GC32961D-3263 hydrochloride
    CAS: 1008763-54-9
    Purity: >98.00%

    D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.