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TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products for  TRP Channel

  1. Cat.No. Product Name Information
  2. GC33675 Podocarpic acid Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator. Podocarpic acid  Chemical Structure
  3. GC12580 Polygodial TRPA1 channel activator Polygodial  Chemical Structure
  4. GC11293 PPAHV

    vanilloid TRPV1 (VR1) receptor agonist

    PPAHV  Chemical Structure
  5. GC65106 Pregnenolone-d4-1 Pregnenolone-d4-1  Chemical Structure
  6. GC16825 Probenecid inhibitor of organic anion transport, MRP and pannexin-1 channel Probenecid  Chemical Structure
  7. GC30096 Pyr10

    Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor.

    Pyr10  Chemical Structure
  8. GC14649 Pyr3 canonical transient receptor potential channel 3 (TRPC3) antagonist Pyr3  Chemical Structure
  9. GC33443 Pyr6 Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). Pyr6  Chemical Structure
  10. GC12783 Resiniferatoxin vanilloid receptors agonist Resiniferatoxin  Chemical Structure
  11. GC44816 Resolvin D2

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

    Resolvin D2  Chemical Structure
  12. GC17267 RN 1734 TRPV4 antagonist RN 1734  Chemical Structure
  13. GC15346 RN 1747 TRPV4 agonist RN 1747  Chemical Structure
  14. GC45907 RN-9893 (hydrochloride) A TRPV4 antagonist RN-9893 (hydrochloride)  Chemical Structure
  15. GC16444 Rosiglitazone

    A PPARγ agonist

    Rosiglitazone  Chemical Structure
  16. GC11318 Rosiglitazone maleate A PPARγ agonist Rosiglitazone maleate  Chemical Structure
  17. GC14635 RQ-00203078 Selective and orally active TRPM8 antagonist RQ-00203078  Chemical Structure
  18. GC33424 SAR7334 SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. SAR7334  Chemical Structure
  19. GC14997 SB 366791 vanilloid TRPV1 receptor antagonist SB 366791  Chemical Structure
  20. GC14248 SB 452533 TRPV1 antagonist SB 452533  Chemical Structure
  21. GC14580 SB705498 TRPV1 antagonist,potent and selective SB705498  Chemical Structure
  22. GC50667 SET 2 SET 2  Chemical Structure
  23. GC14641 SKF 96365 hydrochloride Store-operated Ca2+ entry (SOCE) inhibitor SKF 96365 hydrochloride  Chemical Structure
  24. GC37655 SN 2 SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2  Chemical Structure
  25. GC69928 SOR-C13 TFA

    SOR-C13 TFA is a carboxy-terminal truncated peptide and a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage-gated calcium channel that is associated with malignant tumors and poor prognosis in breast cancer. SOR-C13 TFA has anti-cancer activity.

    SOR-C13 TFA  Chemical Structure
  26. GC15417 STEARDA potentiates TRPV1-mediated effects of NADA STEARDA  Chemical Structure
  27. GC15208 TC-I 2000 TRPM8 channel blocker TC-I 2000  Chemical Structure
  28. GC34833 TC-I 2014 TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014  Chemical Structure
  29. GC11185 TCS 5861528 TCS 5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. TCS 5861528  Chemical Structure
  30. GC64852 Tivanisiran Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran  Chemical Structure
  31. GC13218 TRPC6 inhibitor TRPC6 inhibitor is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. TRPC6 inhibitor  Chemical Structure
  32. GC30546 TRPC6-IN-1 TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM. TRPC6-IN-1  Chemical Structure
  33. GC70066 TRPC6-IN-3

    TRPC6-IN-3 (compound 17) is an orally effective inhibitor of transient receptor potential cation channel subfamily C member 6 (TRPC6). TRPC6-IN-3 can not only regulate intracellular calcium concentration, but also modulate membrane potential by regulating cation flux including calcium and sodium ions. TRPC6-IN-3 can be used for research in the respiratory system.

    TRPC6-IN-3  Chemical Structure
  34. GC50590 TRPC6-PAM-C20 Selective TRPC6 positive allosteric modulator TRPC6-PAM-C20  Chemical Structure
  35. GC68002 TRPM4-IN-2 TRPM4-IN-2  Chemical Structure
  36. GC37831 TRPM8 agonist WS-3 TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3  Chemical Structure
  37. GC30893 TRPM8 Antagonist TRPM8 Antagonist is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 Antagonist  Chemical Structure
  38. GC64086 TRPM8 antagonist 3 TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM. TRPM8 antagonist 3  Chemical Structure
  39. GC30725 TRPV antagonist 1

    TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC50 of < 250 nM.

    TRPV antagonist 1  Chemical Structure
  40. GC70067 TRPV1 antagonist 3

    TRPV1 antagonist 3 (Compound 7q) is an effective TRPV1 antagonist with an IC50 value of 2.66 nM against capsaicin. It has mode selectivity and good oral bioavailability (F = 60%), and can penetrate the blood-brain barrier.

    TRPV1 antagonist 3  Chemical Structure
  41. GC65536 TRPV4 agonist-1 TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay. TRPV4 agonist-1  Chemical Structure
  42. GC63244 TRPV4 agonist-1 free base TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay. TRPV4 agonist-1 free base  Chemical Structure
  43. GC65211 Umbellulone Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone  Chemical Structure
  44. GC63249 Vanilloid receptor antagonist 1 Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist extracted from patent US8349852B2, compound B8. Vanilloid receptor antagonist 1  Chemical Structure
  45. GC16760 WS 12 TRPM8 agonist WS 12  Chemical Structure
  46. GC14387 WS 3 TRPM8 receptor agonist WS 3  Chemical Structure

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