GLPBio

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products Related to TRP Channel(184)

  • GC63244 structure
    GC63244TRPV4 agonist-1 free base
    CAS: 2314467-59-7
    Purity: >99.50%

    TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC 50 value of 60nM in the hTRPV4 Ca 2+ test.

  • GC63249 structure
    GC63249Vanilloid receptor antagonist 1
    CAS: 871814-52-7
    Purity: >98.00%

    Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist extracted from patent US8349852B2, compound B8.

  • GC64062 structure
    GC64062(1R,2R)-ML-SI3
    CAS: 2418594-00-8
    Purity: >98.00%

    (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.

  • GC64086 structure
    GC64086TRPM8 antagonist 3
    CAS: 2102179-29-1
    Purity: >98%

    TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM.

  • GC64459 structure
    GC64459Englerin A
    CAS: 1094250-15-3
    Purity: >99.00%

    Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.

  • GC64573 structure
    GC64573PF-04745637
    CAS: 1917294-46-2
    Purity: >97.00%

    PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.

  • GC64852 structure
    GC64852Tivanisiran
    CAS: 1848224-71-4
    Purity: >92.50%

    Tivanisiran is a small interfering RNA (siRNA) drug with topical ophthalmic activity that targets and induces the degradation of TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) mRNA.

  • GC65006 structure
    GC65006JNc-440
    CAS: 1119503-63-7
    Purity: >98%

    JNc-440 is a potent antihypertensive agent.

  • GC65106 structure
    GC65106Pregnenolone-d4-1
    CAS: 61574-54-7
    Purity: >98.00%
  • GC65211 structure
    GC65211Umbellulone
    CAS: 546-78-1
    Purity: >98%

    Umbellulone is an active constituent of the leaves of Umbellularia californica.

  • GC65536 structure
    GC65536TRPV4 agonist-1
    CAS: 2314467-60-0
    Purity: >98%

    TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC 50 value of 60nM in the hTRPV4 Ca 2+ test.

  • GC65611 structure
    GC65611AMG 333
    CAS: 1416799-28-4
    Purity: >99.00%

    AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

  • GC66016 structure
    GC66016Evifacotrep
    CAS: 2413739-88-3
    Purity: >99.00%

    Evifacotrep, a short transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases.

  • GC66436 structure
    GC66436FEMA 4809
    CAS: 1374760-95-8
    Purity: >99.00%

    FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception.

  • GC67739 structure
    GC67739D-erythro-Sphingosine hydrochloride
    CAS: 2673-72-5
    Purity: >97.00%
  • GC67784 structure
    GC67784ML-SI3
    CAS: 891016-02-7
    Purity: >99.00%

    ML-SI3 is cation channel TRPML inhibitor, with IC 50 values of 4.7μM and 1.7μM for TRPML1 and TRPML2, respectively.

  • GC67924 structure
    GC67924Dihydrocapsiate
    CAS: 205687-03-2
    Purity: >99.00%
  • GC68002 structure
    GC68002TRPM4-IN-2
    CAS: 667411-04-3
    Purity: >98.00%

    TRPM4-IN-2 is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC 50 value of 0.16μM.

  • GC68080 structure
    GC680804-(Phenyldiazenyl)benzoic acid
    CAS: 1562-93-2
    Purity: >98%
  • GC68735 structure
    GC68735BAY-390
    CAS: 2741956-55-6
    Purity: >98%

    BAY-390 is a selective, cross-species active, and brain-penetrant TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50 values of 16, 82, 63 and 35 nM respectively. BAY-390 can be used for research on inflammation.

  • GC69317 structure
    GC69317JNJ-28583113
    CAS: 2765255-93-2
    Purity: >98.00%

    JNJ-28583113 is a brain-penetrant TRPM2 antagonist. It inhibits the phosphorylation of GSK3α and β subunits by blocking TRPM2. JNJ-28583113 protects cells from oxidative stress-induced cell death. It also inhibits the release of cytokines from microglia in response to pro-inflammatory stimuli.

  • GC69450 structure
    GC69450Mesendogen
    CAS: 864716-85-8
    Purity: >99.00%

    Mesendogen is a TRPM6 inhibitor. It promotes mesoderm and endoderm differentiation of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for studying magnesium homeostasis during early embryonic cell development.

  • GC69478 structure
    GC69478ML-SA5
    CAS: 2418670-70-7
    Purity: >99.50%

    ML-SA5 is a potent TRPML1 cation channel agonist that can activate the entire intracellular TRPML1 (ML1) current in DMD muscle cells, with an EC50 value of 285 nM, which is more effective than ML-SA1. ML-SA5 has anti-cancer activity and can inhibit tumor growth.

  • GC69508 structure
    GC69508MSP-3
    CAS: 1820968-63-5
    Purity: >98.00%

    MSP-3 is an effective TRPV1 agonist with an EC50 value of 0.87 μM. MSP-3 has neuroprotective effects.