GLPBio

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products Related to TRP Channel(184)

  • GC69928 structure
    GC69928SOR-C13 TFA
    Purity: >99.00%

    SOR-C13 TFA is a carboxy-terminal truncated peptide and a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage-gated calcium channel that is associated with malignant tumors and poor prognosis in breast cancer. SOR-C13 TFA has anti-cancer activity.

  • GC70066 structure
    GC70066TRPC6-IN-3
    CAS: 2311863-36-0
    Purity: >99.00%

    TRPC6-IN-3 (compound 17) is an orally effective inhibitor of transient receptor potential cation channel subfamily C member 6 (TRPC6). TRPC6-IN-3 can not only regulate intracellular calcium concentration, but also modulate membrane potential by regulating cation flux including calcium and sodium ions. TRPC6-IN-3 can be used for research in the respiratory system.

  • GC70067 structure
    GC70067TRPV1 antagonist 3
    Purity: >99.00%

    TRPV1 antagonist 3 (Compound 7q) is an effective TRPV1 antagonist with an IC50 value of 2.66 nM against capsaicin. It has mode selectivity and good oral bioavailability (F = 60%), and can penetrate the blood-brain barrier.

  • GC70305 structure
    GC70305Elismetrep
    CAS: 1400699-64-0
    Purity: >99.00%

    Elismetrep (MT-8554) is an oral active TRPM8 inhibitor, and can be used for study of analgesic.

  • GC70321 structure
    GC70321TRPV1 antagonist 5
    CAS: 878811-00-8

    TRPV1 antagonist 5 (compound 1) is a potent TRPV1 antagonist.

  • GC70412 structure
    GC70412GDC-0334
    CAS: 1984824-54-5

    GDC-0334 is a selective TRPA1 antagonist.

  • GC70676 structure
    GC70676Tivanisiran sodium
    CAS: 1848239-71-3
    Purity: >92.00%

    Tivanisiran sodium is a small interfering RNA (siRNA) drug with topical ophthalmic activity that targets and induces the degradation of TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) mRNA.

  • GC70794 structure
    GC70794Palvanil
    CAS: 69693-13-6

    Palvanil is a Capsaicin analogue, shows strong desensitizing capability against the TRPV1 receptor.

  • GC71398 structure
    GC71398GDC-6599
    CAS: 2376824-99-4
    Purity: >99.00%

    GDC-6599 (Example 8) is an orally active TRPA1 inhibitor.

  • GC71419 structure
    GC71419TRPV2-selective blocker 1
    CAS: 2242724-49-6
    Purity: >99.50%

    TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM.

  • GC72821 structure
    GC72821RN-9893
    CAS: 1803003-68-0
    Purity: >99.00%

    RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.

  • GC73042 structure
    GC73042(1S,2S)-ML-SI3
    CAS: 2563870-87-9
    Purity: >99.00%

    (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML.

  • GC73075 structure
    GC73075(rel)-ML-SI3
    CAS: 2108567-79-7
    Purity: >99.00%

    (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML.

  • GC73917 structure
    GC73917RN-1665
    CAS: 1803003-65-7
    Purity: >99.00%

    RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8.

  • GC74344 structure
    GC74344SOR-C13
    CAS: 1187852-48-7
    Purity: >98.00%

    SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM.

  • GC74345 structure
    GC74345SOR-C13 acetate
    Purity: >98.00%

    SOR-C13 acetate is the acetate salt form of SOR-C13.

  • GC74418 structure
    GC74418Wasabi Receptor Toxin TFA
    Purity: >99.00%

    Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin.

  • GC79519 structure
    GC79519SKF-96365
    CAS: 162849-90-3
    Purity: >99.50%

    SKF-96365 is a TRPC channel antagonist and store-operated calcium entry ( SOCE ) inhibitor.

  • GC79522 structure
    GC79522TRPA1 agonist-3
    CAS: 3083086-77-2
    Purity: >99.50%

    TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, with EC 50 values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively.

  • GC79523 structure
    GC79523Indazapyroxamet
    CAS: 1689545-27-4
    Purity: >98%

    Indazapyroxamet is an orally active insect TRPV channel (Nan/Iav subunit) modulator and insecticide.

  • GC79524 structure
    GC79524ADM 12
    CAS: 1644134-60-0
    Purity: >98.50%

    ADM 12 is a highly selective transient receptor potential ankyrin 1 ( TRPA1 ) channel antagonist.

  • GC79525 structure
    GC79525TRPM3-IN-1
    CAS: 2776193-88-3
    Purity: >98.00%

    TRPM3-IN-1 (compound 124) is an inhibitor of TRPM3 with an IC 50 value <1 µM.

  • GC79526 structure
    GC79526AM-0883
    Purity: >98.50%

    AM-0883 is a TRPC6 (Transient receptor potential canonical 6) agonist ( hTRPC6 EC 50 = 46 nM).

  • GC79527 structure
    GC79527AMG-8562
    CAS: 1041478-78-7
    Purity: >98%

    AMG-8562 is a selective, orally active transient receptor potential vanilloid 1 ( TRPV1 ) modulator that inhibits the activation of rat TRPV1 by Capsaicin, Anandamide and N-arachidonyldopamine, with IC 50 values of 1.75, 9.29 and 3.87 nM, respectively.